Glutathione peroxidase 4: a new player in neurodegeneration?
Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was initially described in cancer cells and has since been identified in hippocampal and renal cells. In this Perspective, we propose...
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| Veröffentlicht in: | Molecular psychiatry 2017-03, Vol.22 (3), p.328-335 |
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| creator | Cardoso, B R Hare, D J Bush, A I Roberts, B R |
| description | Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was initially described in cancer cells and has since been identified in hippocampal and renal cells. In this Perspective, we propose that inhibition of ferroptosis by GPx4 provides protective mechanisms against neurodegeneration. In addition, we suggest that selenium deficiency enhances susceptibility to ferroptotic processes, as well as other programmed cell death pathways due to a reduction in GPx4 activity. We review recent studies of GPx4 with an emphasis on neuronal protection, and discuss the relevance of selenium levels on its enzymatic activity. |
| doi_str_mv | 10.1038/mp.2016.196 |
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Hare, D J ; Bush, A I ; Roberts, B R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c615t-49b3229602a67993efbf302b0745b759f0c46473341b50dfe38b5744ed58f4243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>631/378</topic><topic>692/699</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Care and treatment</topic><topic>Cell death</topic><topic>Cell Death - physiology</topic><topic>Cytoplasm</topic><topic>Degeneration</topic><topic>Development and progression</topic><topic>Enzymatic activity</topic><topic>Enzyme activation</topic><topic>Enzymes</topic><topic>Ferroptosis</topic><topic>Genetic aspects</topic><topic>Glutathione peroxidase</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Peroxidase - physiology</topic><topic>Health aspects</topic><topic>Hippocampus</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental health</topic><topic>Nerve degeneration</topic><topic>Nervous system</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative Diseases - prevention & control</topic><topic>Neurons</topic><topic>Neurosciences</topic><topic>Oxidative stress</topic><topic>Peroxidase</topic><topic>perspective</topic><topic>Pharmacotherapy</topic><topic>Physiology</topic><topic>Psychiatry</topic><topic>Selenium</topic><topic>Selenium (Nutrient)</topic><topic>Selenium - metabolism</topic><topic>Sperm</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cardoso, B R</creatorcontrib><creatorcontrib>Hare, D J</creatorcontrib><creatorcontrib>Bush, A I</creatorcontrib><creatorcontrib>Roberts, B R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cardoso, B R</au><au>Hare, D J</au><au>Bush, A I</au><au>Roberts, B R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione peroxidase 4: a new player in neurodegeneration?</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>22</volume><issue>3</issue><spage>328</spage><epage>335</epage><pages>328-335</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was initially described in cancer cells and has since been identified in hippocampal and renal cells. In this Perspective, we propose that inhibition of ferroptosis by GPx4 provides protective mechanisms against neurodegeneration. In addition, we suggest that selenium deficiency enhances susceptibility to ferroptotic processes, as well as other programmed cell death pathways due to a reduction in GPx4 activity. We review recent studies of GPx4 with an emphasis on neuronal protection, and discuss the relevance of selenium levels on its enzymatic activity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27777421</pmid><doi>10.1038/mp.2016.196</doi><tpages>8</tpages></addata></record> |
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| ispartof | Molecular psychiatry, 2017-03, Vol.22 (3), p.328-335 |
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| subjects | 631/378 692/699 Animals Antioxidants Apoptosis Behavioral Sciences Biological Psychology Care and treatment Cell death Cell Death - physiology Cytoplasm Degeneration Development and progression Enzymatic activity Enzyme activation Enzymes Ferroptosis Genetic aspects Glutathione peroxidase Glutathione Peroxidase - metabolism Glutathione Peroxidase - physiology Health aspects Hippocampus Humans Medicine Medicine & Public Health Mental health Nerve degeneration Nervous system Neurodegeneration Neurodegenerative Diseases - prevention & control Neurons Neurosciences Oxidative stress Peroxidase perspective Pharmacotherapy Physiology Psychiatry Selenium Selenium (Nutrient) Selenium - metabolism Sperm Vitamin E |
| title | Glutathione peroxidase 4: a new player in neurodegeneration? |
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