Magnetic resonance imaging to assess the effect of exercise training on pulmonary perfusion and blood flow in patients with pulmonary hypertension
Objectives To evaluate whether careful exercise training improves pulmonary perfusion and blood flow in patients with pulmonary hypertension (PH), as assessed by magnetic resonance imaging (MR). Methods Twenty patients with pulmonary arterial hypertension or inoperable chronic thromboembolic PH on s...
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| Veröffentlicht in: | European radiology 2013-02, Vol.23 (2), p.324-331 |
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| creator | Ley, Sebastian Fink, Christian Risse, Frank Ehlken, Nicola Fischer, Christine Ley-Zaporozhan, Julia Kauczor, Hans-Ulrich Klose, Hans Gruenig, Ekkehard |
| description | Objectives
To evaluate whether careful exercise training improves pulmonary perfusion and blood flow in patients with pulmonary hypertension (PH), as assessed by magnetic resonance imaging (MR).
Methods
Twenty patients with pulmonary arterial hypertension or inoperable chronic thromboembolic PH on stable medication were randomly assigned to control (
n
= 10) or training groups (
n
= 10). Training group patients received in-hospital exercise training; patients of the sedentary control group received conventional rehabilitation. Medication remained unchanged during the study period. Changes of 6-min walking distance (6MWD), MR pulmonary flow (peak velocity) and MR perfusion (pulmonary blood volume) were assessed from baseline to week 3.
Results
After 3 weeks of training, increases in mean 6MWD (
P
= 0.004) and mean MR flow peak velocity (
P
= 0.012) were significantly greater in the training group. Training group patients had significantly improved 6MWD (
P
= 0.008), MR flow (peak velocity −9.7 ± 8.6 cm/s,
P
= 0.007) and MR perfusion (pulmonary blood volume +2.2 ± 2.7 mL/100 mL,
P
= 0.017), whereas the control group showed no significant changes.
Conclusion
The study indicates that respiratory and physical exercise may improve pulmonary perfusion in patients with PH. Measurement of MR parameters of pulmonary perfusion might be an interesting new method to assess therapy effects in PH. The results of this initial study should be confirmed in a larger study group.
Key Points
•
Quantification of magnetic resonance perfusion is feasible in patients with pulmonary hypertension.
•
Quantified magnetic resonance perfusion may become useful for non-invasive monitoring of treatment.
•
Quantification of lung perfusion allows new insights into lung (patho-)physiology of PH.
•
Careful exercise training improves pulmonary perfusion and blood flow in patients with PH. |
| doi_str_mv | 10.1007/s00330-012-2606-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1897372628</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1897372628</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-2103ecb6a94ad23786c1ca07c25543aadcb875d1c0a46d5fc0c6c5e0ffca8e493</originalsourceid><addsrcrecordid>eNqFkc2KFDEURoMoTtv6AG4k4GY25dz8VFVqKYOjwshsdB3SqZvuDNVJm6QYex7DJzZFjzII4iqQnO-73BxCXjN4xwD6iwwgBDTAeMM76Jr7J2TFpOANAyWfkhUMQjX9MMgz8iLnWwAYmOyfkzPOleraVqzIzy9mG7B4SxPmGEywSP3ebH3Y0hKpyRlzpmWHFJ1DW2h0FH9gsj4jLcn4sJAx0MM87Ws-HekBk5uzr3cmjHQzxThSN8U76itlisdQMr3zZfcoszvWVMGwxF6SZ85MGV89nGvy7erD18tPzfXNx8-X768bK6EtDWcg0G46M0gzctGrzjJroLe8baUwZrQb1bcjs2BkN7bOgu1si-CcNQrlINbk_NR7SPH7jLnovc8Wp8kEjHPWTA296HnH1f9RXkkpl8Fr8vYv9DbOKdRFFqr6GkAuhexE2RRzTuj0IdVvT0fNQC9u9cmtrm714lbf18ybh-Z5s8fxT-K3zArwE5DrU9hiejT6n62_AMNMsrc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1270339048</pqid></control><display><type>article</type><title>Magnetic resonance imaging to assess the effect of exercise training on pulmonary perfusion and blood flow in patients with pulmonary hypertension</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ley, Sebastian ; Fink, Christian ; Risse, Frank ; Ehlken, Nicola ; Fischer, Christine ; Ley-Zaporozhan, Julia ; Kauczor, Hans-Ulrich ; Klose, Hans ; Gruenig, Ekkehard</creator><creatorcontrib>Ley, Sebastian ; Fink, Christian ; Risse, Frank ; Ehlken, Nicola ; Fischer, Christine ; Ley-Zaporozhan, Julia ; Kauczor, Hans-Ulrich ; Klose, Hans ; Gruenig, Ekkehard</creatorcontrib><description>Objectives
To evaluate whether careful exercise training improves pulmonary perfusion and blood flow in patients with pulmonary hypertension (PH), as assessed by magnetic resonance imaging (MR).
Methods
Twenty patients with pulmonary arterial hypertension or inoperable chronic thromboembolic PH on stable medication were randomly assigned to control (
n
= 10) or training groups (
n
= 10). Training group patients received in-hospital exercise training; patients of the sedentary control group received conventional rehabilitation. Medication remained unchanged during the study period. Changes of 6-min walking distance (6MWD), MR pulmonary flow (peak velocity) and MR perfusion (pulmonary blood volume) were assessed from baseline to week 3.
Results
After 3 weeks of training, increases in mean 6MWD (
P
= 0.004) and mean MR flow peak velocity (
P
= 0.012) were significantly greater in the training group. Training group patients had significantly improved 6MWD (
P
= 0.008), MR flow (peak velocity −9.7 ± 8.6 cm/s,
P
= 0.007) and MR perfusion (pulmonary blood volume +2.2 ± 2.7 mL/100 mL,
P
= 0.017), whereas the control group showed no significant changes.
Conclusion
The study indicates that respiratory and physical exercise may improve pulmonary perfusion in patients with PH. Measurement of MR parameters of pulmonary perfusion might be an interesting new method to assess therapy effects in PH. The results of this initial study should be confirmed in a larger study group.
Key Points
•
Quantification of magnetic resonance perfusion is feasible in patients with pulmonary hypertension.
•
Quantified magnetic resonance perfusion may become useful for non-invasive monitoring of treatment.
•
Quantification of lung perfusion allows new insights into lung (patho-)physiology of PH.
•
Careful exercise training improves pulmonary perfusion and blood flow in patients with PH.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-012-2606-z</identifier><identifier>PMID: 22886553</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Anticoagulants ; Awards & honors ; Blood ; Blood Flow Velocity ; Chest ; Diagnostic Radiology ; Diuretics ; Exercise Therapy - methods ; Female ; Fitness training programs ; Follow-Up Studies ; Heart failure ; Hospitals ; Humans ; Hypertension, Pulmonary - diagnosis ; Hypertension, Pulmonary - rehabilitation ; Imaging ; Imaging, Three-Dimensional - methods ; Internal Medicine ; Interventional Radiology ; Magnetic Resonance Angiography - methods ; Magnetic resonance imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Musculoskeletal system ; Neuroradiology ; Perfusion ; Prospective Studies ; Pulmonary arteries ; Pulmonary Circulation - physiology ; Pulmonary hypertension ; Quality of Life ; Radiology ; Reference Values ; Respiratory Therapy - methods ; Risk Assessment ; Severity of Illness Index ; Thromboembolism ; Treatment Outcome ; Ultrasound ; Velocity</subject><ispartof>European radiology, 2013-02, Vol.23 (2), p.324-331</ispartof><rights>European Society of Radiology 2012</rights><rights>European Society of Radiology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-2103ecb6a94ad23786c1ca07c25543aadcb875d1c0a46d5fc0c6c5e0ffca8e493</citedby><cites>FETCH-LOGICAL-c405t-2103ecb6a94ad23786c1ca07c25543aadcb875d1c0a46d5fc0c6c5e0ffca8e493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-012-2606-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-012-2606-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22886553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ley, Sebastian</creatorcontrib><creatorcontrib>Fink, Christian</creatorcontrib><creatorcontrib>Risse, Frank</creatorcontrib><creatorcontrib>Ehlken, Nicola</creatorcontrib><creatorcontrib>Fischer, Christine</creatorcontrib><creatorcontrib>Ley-Zaporozhan, Julia</creatorcontrib><creatorcontrib>Kauczor, Hans-Ulrich</creatorcontrib><creatorcontrib>Klose, Hans</creatorcontrib><creatorcontrib>Gruenig, Ekkehard</creatorcontrib><title>Magnetic resonance imaging to assess the effect of exercise training on pulmonary perfusion and blood flow in patients with pulmonary hypertension</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To evaluate whether careful exercise training improves pulmonary perfusion and blood flow in patients with pulmonary hypertension (PH), as assessed by magnetic resonance imaging (MR).
Methods
Twenty patients with pulmonary arterial hypertension or inoperable chronic thromboembolic PH on stable medication were randomly assigned to control (
n
= 10) or training groups (
n
= 10). Training group patients received in-hospital exercise training; patients of the sedentary control group received conventional rehabilitation. Medication remained unchanged during the study period. Changes of 6-min walking distance (6MWD), MR pulmonary flow (peak velocity) and MR perfusion (pulmonary blood volume) were assessed from baseline to week 3.
Results
After 3 weeks of training, increases in mean 6MWD (
P
= 0.004) and mean MR flow peak velocity (
P
= 0.012) were significantly greater in the training group. Training group patients had significantly improved 6MWD (
P
= 0.008), MR flow (peak velocity −9.7 ± 8.6 cm/s,
P
= 0.007) and MR perfusion (pulmonary blood volume +2.2 ± 2.7 mL/100 mL,
P
= 0.017), whereas the control group showed no significant changes.
Conclusion
The study indicates that respiratory and physical exercise may improve pulmonary perfusion in patients with PH. Measurement of MR parameters of pulmonary perfusion might be an interesting new method to assess therapy effects in PH. The results of this initial study should be confirmed in a larger study group.
Key Points
•
Quantification of magnetic resonance perfusion is feasible in patients with pulmonary hypertension.
•
Quantified magnetic resonance perfusion may become useful for non-invasive monitoring of treatment.
•
Quantification of lung perfusion allows new insights into lung (patho-)physiology of PH.
•
Careful exercise training improves pulmonary perfusion and blood flow in patients with PH.</description><subject>Adult</subject><subject>Aged</subject><subject>Anticoagulants</subject><subject>Awards & honors</subject><subject>Blood</subject><subject>Blood Flow Velocity</subject><subject>Chest</subject><subject>Diagnostic Radiology</subject><subject>Diuretics</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>Fitness training programs</subject><subject>Follow-Up Studies</subject><subject>Heart failure</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - diagnosis</subject><subject>Hypertension, Pulmonary - rehabilitation</subject><subject>Imaging</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic Resonance Angiography - methods</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Musculoskeletal system</subject><subject>Neuroradiology</subject><subject>Perfusion</subject><subject>Prospective Studies</subject><subject>Pulmonary arteries</subject><subject>Pulmonary Circulation - physiology</subject><subject>Pulmonary hypertension</subject><subject>Quality of Life</subject><subject>Radiology</subject><subject>Reference Values</subject><subject>Respiratory Therapy - methods</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>Thromboembolism</subject><subject>Treatment Outcome</subject><subject>Ultrasound</subject><subject>Velocity</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc2KFDEURoMoTtv6AG4k4GY25dz8VFVqKYOjwshsdB3SqZvuDNVJm6QYex7DJzZFjzII4iqQnO-73BxCXjN4xwD6iwwgBDTAeMM76Jr7J2TFpOANAyWfkhUMQjX9MMgz8iLnWwAYmOyfkzPOleraVqzIzy9mG7B4SxPmGEywSP3ebH3Y0hKpyRlzpmWHFJ1DW2h0FH9gsj4jLcn4sJAx0MM87Ws-HekBk5uzr3cmjHQzxThSN8U76itlisdQMr3zZfcoszvWVMGwxF6SZ85MGV89nGvy7erD18tPzfXNx8-X768bK6EtDWcg0G46M0gzctGrzjJroLe8baUwZrQb1bcjs2BkN7bOgu1si-CcNQrlINbk_NR7SPH7jLnovc8Wp8kEjHPWTA296HnH1f9RXkkpl8Fr8vYv9DbOKdRFFqr6GkAuhexE2RRzTuj0IdVvT0fNQC9u9cmtrm714lbf18ybh-Z5s8fxT-K3zArwE5DrU9hiejT6n62_AMNMsrc</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Ley, Sebastian</creator><creator>Fink, Christian</creator><creator>Risse, Frank</creator><creator>Ehlken, Nicola</creator><creator>Fischer, Christine</creator><creator>Ley-Zaporozhan, Julia</creator><creator>Kauczor, Hans-Ulrich</creator><creator>Klose, Hans</creator><creator>Gruenig, Ekkehard</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Magnetic resonance imaging to assess the effect of exercise training on pulmonary perfusion and blood flow in patients with pulmonary hypertension</title><author>Ley, Sebastian ; Fink, Christian ; Risse, Frank ; Ehlken, Nicola ; Fischer, Christine ; Ley-Zaporozhan, Julia ; Kauczor, Hans-Ulrich ; Klose, Hans ; Gruenig, Ekkehard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-2103ecb6a94ad23786c1ca07c25543aadcb875d1c0a46d5fc0c6c5e0ffca8e493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anticoagulants</topic><topic>Awards & honors</topic><topic>Blood</topic><topic>Blood Flow Velocity</topic><topic>Chest</topic><topic>Diagnostic Radiology</topic><topic>Diuretics</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>Fitness training programs</topic><topic>Follow-Up Studies</topic><topic>Heart failure</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - diagnosis</topic><topic>Hypertension, Pulmonary - rehabilitation</topic><topic>Imaging</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic Resonance Angiography - methods</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Musculoskeletal system</topic><topic>Neuroradiology</topic><topic>Perfusion</topic><topic>Prospective Studies</topic><topic>Pulmonary arteries</topic><topic>Pulmonary Circulation - physiology</topic><topic>Pulmonary hypertension</topic><topic>Quality of Life</topic><topic>Radiology</topic><topic>Reference Values</topic><topic>Respiratory Therapy - methods</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>Thromboembolism</topic><topic>Treatment Outcome</topic><topic>Ultrasound</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ley, Sebastian</creatorcontrib><creatorcontrib>Fink, Christian</creatorcontrib><creatorcontrib>Risse, Frank</creatorcontrib><creatorcontrib>Ehlken, Nicola</creatorcontrib><creatorcontrib>Fischer, Christine</creatorcontrib><creatorcontrib>Ley-Zaporozhan, Julia</creatorcontrib><creatorcontrib>Kauczor, Hans-Ulrich</creatorcontrib><creatorcontrib>Klose, Hans</creatorcontrib><creatorcontrib>Gruenig, Ekkehard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ley, Sebastian</au><au>Fink, Christian</au><au>Risse, Frank</au><au>Ehlken, Nicola</au><au>Fischer, Christine</au><au>Ley-Zaporozhan, Julia</au><au>Kauczor, Hans-Ulrich</au><au>Klose, Hans</au><au>Gruenig, Ekkehard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance imaging to assess the effect of exercise training on pulmonary perfusion and blood flow in patients with pulmonary hypertension</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>23</volume><issue>2</issue><spage>324</spage><epage>331</epage><pages>324-331</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To evaluate whether careful exercise training improves pulmonary perfusion and blood flow in patients with pulmonary hypertension (PH), as assessed by magnetic resonance imaging (MR).
Methods
Twenty patients with pulmonary arterial hypertension or inoperable chronic thromboembolic PH on stable medication were randomly assigned to control (
n
= 10) or training groups (
n
= 10). Training group patients received in-hospital exercise training; patients of the sedentary control group received conventional rehabilitation. Medication remained unchanged during the study period. Changes of 6-min walking distance (6MWD), MR pulmonary flow (peak velocity) and MR perfusion (pulmonary blood volume) were assessed from baseline to week 3.
Results
After 3 weeks of training, increases in mean 6MWD (
P
= 0.004) and mean MR flow peak velocity (
P
= 0.012) were significantly greater in the training group. Training group patients had significantly improved 6MWD (
P
= 0.008), MR flow (peak velocity −9.7 ± 8.6 cm/s,
P
= 0.007) and MR perfusion (pulmonary blood volume +2.2 ± 2.7 mL/100 mL,
P
= 0.017), whereas the control group showed no significant changes.
Conclusion
The study indicates that respiratory and physical exercise may improve pulmonary perfusion in patients with PH. Measurement of MR parameters of pulmonary perfusion might be an interesting new method to assess therapy effects in PH. The results of this initial study should be confirmed in a larger study group.
Key Points
•
Quantification of magnetic resonance perfusion is feasible in patients with pulmonary hypertension.
•
Quantified magnetic resonance perfusion may become useful for non-invasive monitoring of treatment.
•
Quantification of lung perfusion allows new insights into lung (patho-)physiology of PH.
•
Careful exercise training improves pulmonary perfusion and blood flow in patients with PH.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22886553</pmid><doi>10.1007/s00330-012-2606-z</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | European radiology, 2013-02, Vol.23 (2), p.324-331 |
| issn | 0938-7994 1432-1084 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Anticoagulants Awards & honors Blood Blood Flow Velocity Chest Diagnostic Radiology Diuretics Exercise Therapy - methods Female Fitness training programs Follow-Up Studies Heart failure Hospitals Humans Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - rehabilitation Imaging Imaging, Three-Dimensional - methods Internal Medicine Interventional Radiology Magnetic Resonance Angiography - methods Magnetic resonance imaging Male Medicine Medicine & Public Health Middle Aged Musculoskeletal system Neuroradiology Perfusion Prospective Studies Pulmonary arteries Pulmonary Circulation - physiology Pulmonary hypertension Quality of Life Radiology Reference Values Respiratory Therapy - methods Risk Assessment Severity of Illness Index Thromboembolism Treatment Outcome Ultrasound Velocity |
| title | Magnetic resonance imaging to assess the effect of exercise training on pulmonary perfusion and blood flow in patients with pulmonary hypertension |
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