CXCL12a/CXCR4b acts to retain neutrophils in caudal hematopoietic tissue and to antagonize recruitment to an injury site in the zebrafish larva

Neutrophils are a major component of the innate immune response and the most abundant circulating cell type in humans and zebrafish. The CXCL12/CXCR4 ligand receptor pair plays a key role in neutrophil homeostasis, controlling definitive hematopoiesis and neutrophil release into circulation. Neutrop...

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Veröffentlicht in:	Immunogenetics (New York) 2017-05, Vol.69 (5), p.341-349
Hauptverfasser:	Paredes-Zúñiga, Susana, Morales, Rodrigo A, Muñoz-Sánchez, Salomé, Muñoz-Montecinos, Carlos, Parada, Margarita, Tapia, Karina, Rubilar, Carlos, Allende, Miguel L, Peña, Oscar A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Animals Animals, Genetically Modified Biomedical and Life Sciences Biomedicine Bone marrow Cell Biology Cells, Cultured Chemokine CXCL12 - immunology Chemokines Danio rerio Embryo, Nonmammalian - cytology Embryo, Nonmammalian - immunology Embryo, Nonmammalian - metabolism Gene Expression Regulation, Developmental Gene Function Genomes Hematopoiesis - immunology Homeostasis Human Genetics Immune response Immunology Infections Inflammation Larva - immunology Larva - metabolism Ligands Neutrophils Neutrophils - immunology Neutrophils - metabolism Neutrophils - pathology Original Article Physiology Receptors, CXCR4 - immunology Zebrafish Zebrafish - immunology Zebrafish - metabolism Zebrafish Proteins - immunology
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