Low Dose Radiation Causes Skin Cancer in Mice and Has a Differential Effect on Distinct Epidermal Stem Cells

The carcinogenic effect of ionizing radiation has been evaluated based on limited populations accidently exposed to high dose radiation. In contrast, insufficient data are available on the effect of low dose radiation (LDR), such as radiation deriving from medical investigations and interventions, a...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2017-05, Vol.35 (5), p.1355-1364
Hauptverfasser:	Revenco, Tatiana, Lapouge, Gaelle, Moers, Virginie, Brohée, Sylvain, Sotiropoulou, Panagiota A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult stem cells Animals Apoptosis Cancer Carcinogens Carcinoma, Basal Cell - pathology Cell death Cell Survival - radiation effects Damage Deoxyribonucleic acid DNA DNA Damage Dose-Response Relationship, Radiation Epidermis Epidermis - radiation effects Exposure Health risks Heterozygote Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Ionizing radiation Metabolism Mice Occupational exposure Occupational health Patched-1 Receptor - metabolism Penetrance Populations Radiation Sebaceous gland Sebaceous Glands - pathology Skin cancer Skin Neoplasms - etiology Skin Neoplasms - pathology Stem cell transplantation Stem cells Stem Cells - metabolism Stem Cells - radiation effects
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