Plasma dipeptidyl peptidase 4 activity correlates with body mass index and the plasma adiponectin concentration in healthy young people
We previously found that plasma dipeptidyl peptidase 4 (DPP4) activity was associated with the development of obesity, type 2 diabetes, and type 1 diabetes using animal models. In this study, we investigated whether DPP4 activity is correlated with the clinical parameters of obesity and/or diabetes...
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| Veröffentlicht in: | Endocrine Journal 2012, Vol.59(10), pp.949-953 |
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| creator | Kirino, Yasushi Sei, Masako Kawazoe, Kazuyoshi Minakuchi, Kazuo Sato, Youichi |
| description | We previously found that plasma dipeptidyl peptidase 4 (DPP4) activity was associated with the development of obesity, type 2 diabetes, and type 1 diabetes using animal models. In this study, we investigated whether DPP4 activity is correlated with the clinical parameters of obesity and/or diabetes in healthy young subjects. Body mass index (BMI), plasma DPP4 activity, total cholesterol, high density lipoprotein (HDL) cholesterol, triglycerides, fasting blood glucose, adiponectin concentration, and body fat were measured in 165 subjects (110 males and 55 females, age 23.2 ± 2.4 years). In correlation analyses, DPP4 activity displayed strong positive correlations with BMI (p = 5.5 × 10-5) and total cholesterol (p = 0.0014), and a negative correlation with the plasma adiponectin concentration (p = 0.013), but not fasting blood glucose. Our findings suggest that plasma DPP4 activity is correlated with the clinical parameters of obesity rather than diabetes in young people. |
| doi_str_mv | 10.1507/endocrj.EJ12-0158 |
| format | Article |
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Our findings suggest that plasma DPP4 activity is correlated with the clinical parameters of obesity rather than diabetes in young people.</description><subject>Adiponectin</subject><subject>Adiponectin - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>Body mass index (BMI)</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Dipeptidyl peptidase 4 (DPP4) activity</subject><subject>Dipeptidyl Peptidase 4 - blood</subject><subject>Female</subject><subject>Healthy young subject</subject><subject>Humans</subject><subject>Male</subject><subject>Obesity - blood</subject><subject>Triglycerides - blood</subject><subject>Young Adult</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb2O1DAURi0EYoeFB6BBLmmy-CeO7RKtFha0EhRQR459Z-NRYgfbA-QJeG08yjAtxfV1cb5ziw-h15TcUEHkOwgu2nS4uftMWUOoUE_QjvJWNa1oyVO0I5qqRmmhr9CLnA-EcC5a_hxdMSaVYFzu0J-vk8mzwc4vsBTv1glvH5MBt9jY4n_6smIbU4LJFMj4ly8jHqJb8Wxyxj44-I1NcLiMgJdNZ6ovBqjpUKPBQijJFB9DxfEIZirjitd4DI_1XFwmeIme7c2U4dV5X6PvH-6-3d43D18-frp9_9BYoUhpnALuHHDJ5GCtJozXaRnbc-IGYEoNIFQ7tEwSbveSdITIlrtBEKd11wG_Rm8375LijyPk0s8-W5gmEyAec0-VlrzTUoj_o5TrjmqieUXphtoUc06w75fkZ5PWnpL-VFV_rqo_VdWfqqqZN2f9cZjBXRL_uqnA_QYccjGPcAFMKt5OcFEKfbpS34v7gtjRpMrxv5_LrUw</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Kirino, Yasushi</creator><creator>Sei, Masako</creator><creator>Kawazoe, Kazuyoshi</creator><creator>Minakuchi, Kazuo</creator><creator>Sato, Youichi</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>2012</creationdate><title>Plasma dipeptidyl peptidase 4 activity correlates with body mass index and the plasma adiponectin concentration in healthy young people</title><author>Kirino, Yasushi ; Sei, Masako ; Kawazoe, Kazuyoshi ; Minakuchi, Kazuo ; Sato, Youichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-d8e3dde3727bcc9023902422f30dbe288be584b42703cf70600743db50d9966e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adiponectin</topic><topic>Adiponectin - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>Body mass index (BMI)</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Dipeptidyl peptidase 4 (DPP4) activity</topic><topic>Dipeptidyl Peptidase 4 - blood</topic><topic>Female</topic><topic>Healthy young subject</topic><topic>Humans</topic><topic>Male</topic><topic>Obesity - blood</topic><topic>Triglycerides - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kirino, Yasushi</creatorcontrib><creatorcontrib>Sei, Masako</creatorcontrib><creatorcontrib>Kawazoe, Kazuyoshi</creatorcontrib><creatorcontrib>Minakuchi, Kazuo</creatorcontrib><creatorcontrib>Sato, Youichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>Endocrine Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kirino, Yasushi</au><au>Sei, Masako</au><au>Kawazoe, Kazuyoshi</au><au>Minakuchi, Kazuo</au><au>Sato, Youichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma dipeptidyl peptidase 4 activity correlates with body mass index and the plasma adiponectin concentration in healthy young people</atitle><jtitle>Endocrine Journal</jtitle><addtitle>Endocr J</addtitle><date>2012</date><risdate>2012</risdate><volume>59</volume><issue>10</issue><spage>949</spage><epage>953</epage><pages>949-953</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>We previously found that plasma dipeptidyl peptidase 4 (DPP4) activity was associated with the development of obesity, type 2 diabetes, and type 1 diabetes using animal models. 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| ispartof | Endocrine Journal, 2012, Vol.59(10), pp.949-953 |
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| subjects | Adiponectin Adiponectin - blood Blood Glucose - metabolism Body Mass Index Body mass index (BMI) Cholesterol - blood Cholesterol, HDL - blood Diabetes Mellitus, Type 2 - blood Dipeptidyl peptidase 4 (DPP4) activity Dipeptidyl Peptidase 4 - blood Female Healthy young subject Humans Male Obesity - blood Triglycerides - blood Young Adult |
| title | Plasma dipeptidyl peptidase 4 activity correlates with body mass index and the plasma adiponectin concentration in healthy young people |
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