The long non-coding RNA Neat1 is an important mediator of the therapeutic effect of bexarotene on traumatic brain injury in mice

Highlights • Bexatrotene up-regulates the level of Neat1 lncRNA in an RXR-α dependent manner. • Knockdown of Neat1 lncRNA induces great mRNA change in expression, which involves in axonal growth. • Over-expression of Neat1 lncRNA promotes axonal growth, but its knockdown inhibits the axonal growth....

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-10, Vol.65, p.183-194
Hauptverfasser:	Zhong, Jianjun, Jiang, Li, Huang, Zhijian, Zhang, Hongrong, Cheng, Chongjie, Liu, Han, He, Junchi, Wu, Jingchuan, Darwazeh, Rami, Wu, Yue, Sun, Xiaochuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Apoptosis - drug effects Bexarotene Brain Injuries, Traumatic - genetics Brain Injuries, Traumatic - metabolism Brain Injuries, Traumatic - therapy Inflammation - metabolism lncRNA Male Mice Mice, Inbred C57BL Neat1 Neurogenesis - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Pidd1 Psychiatry RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Long Noncoding - therapeutic use RXR TBI Tetrahydronaphthalenes - pharmacology Tetrahydronaphthalenes - therapeutic use Up-Regulation - drug effects
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Zusammenfassung:	Highlights • Bexatrotene up-regulates the level of Neat1 lncRNA in an RXR-α dependent manner. • Knockdown of Neat1 lncRNA induces great mRNA change in expression, which involves in axonal growth. • Over-expression of Neat1 lncRNA promotes axonal growth, but its knockdown inhibits the axonal growth. • Neat1 lncRNA directly captures many kinds of protein, including Pidd1 protein. • Neat1 lncRNA inhibits cell apoptosis and restricts inflammatory reaction by restraining Pidd1.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2017.05.001