Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)‑ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis

Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)‑ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis

An asymmetric dual-metal relay catalysis strategy that combines Rh/chiral sulfur-olefin-catalyzed enantioselective 1,2-addition with a Pd-catalyzed intramolecular C–O coupling has been developed. The method allows rapid and efficient synthesis of quaternary carbon-containing gem-diaryl benzofuran-3­...

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Veröffentlicht in:Organic letters 2017-05, Vol.19 (10), p.2726-2729
Hauptverfasser: Zhang, Zong-Feng, Zhu, Dong-Xing, Chen, Wen-Wen, Xu, Bin, Xu, Ming-Hua
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container_issue 10
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container_title Organic letters
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creator Zhang, Zong-Feng
Zhu, Dong-Xing
Chen, Wen-Wen
Xu, Bin
Xu, Ming-Hua
description An asymmetric dual-metal relay catalysis strategy that combines Rh/chiral sulfur-olefin-catalyzed enantioselective 1,2-addition with a Pd-catalyzed intramolecular C–O coupling has been developed. The method allows rapid and efficient synthesis of quaternary carbon-containing gem-diaryl benzofuran-3­(2H)-ones in good yields in a highly enantioselective manner (up to 99% ee) through a simple one-pot cascade reaction.
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title Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)‑ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis
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