Safety and Efficacy of Chloral Hydrate Sedation in Paediatric Sedation for Ophthalmic Procedures
Chloral hydrate (CH) sedation is routinely used in paediatric ophthalmic examination in Singapore as an alternative to examination under general anaesthesia. Despite CH's traditionally high success rates and relatively low rate of adverse events, there is little data on its safety and efficacy...
Gespeichert in:
| Veröffentlicht in: | Annals of the Academy of Medicine, Singapore Singapore, 2017-04, Vol.46 (4), p.138-144 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 144 |
|---|---|
| container_issue | 4 |
| container_start_page | 138 |
| container_title | Annals of the Academy of Medicine, Singapore |
| container_volume | 46 |
| creator | Chan, Amy Mh Tan, Geok Koon Loh, Huey Peng Lim, Sock Huang Chia, Audrey Wl |
| description | Chloral hydrate (CH) sedation is routinely used in paediatric ophthalmic examination in Singapore as an alternative to examination under general anaesthesia. Despite CH's traditionally high success rates and relatively low rate of adverse events, there is little data on its safety and efficacy as a sedative for ophthalmic procedures in an Asian population.
A retrospective chart review was performed, including children who underwent CH sedation at the Singapore National Eye Centre from January 2012 to January 2015. Participants were given an initial dose of CH and a top-up dose if required. Univariate and multivariate analyses were performed on data collected.
CH sedation was successful in 144 of 153 children (94.1%). Of the 20 (13.0%) who required a top-up dose, 4 failed to sedate. The mean sedation onset was 29.4 minutes (SD: 24.3) and mean sedation duration was 56.5 minutes (SD: 24.0), with more than a third lasting more than 1 hour. The age of children, rather than initial dose of CH, was more relevant in determining success of sedation. Children who were >6 years old were 20.3 times more likely to fail sedation than those aged |
| doi_str_mv | 10.47102/annals-acadmedsg.V46N4p138 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1896895576</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1896895576</sourcerecordid><originalsourceid>FETCH-LOGICAL-c374t-ff5fe4108f5f055baee84a998383bbb53bb92e324c80abf534e88e0a7463718b3</originalsourceid><addsrcrecordid>eNpNkE1PwzAMhiMEYmPwF1AkLlw6kiZpU3FC02BIE5s04Frc1GFF_RhJe-i_p2IwuNiW_b629RByxdlUxpyFN1DXUPoADOQV5v59-iqjJ7njQh-RMRNMBjJi4fG_ekTOvP9gTMYsjE7JKNRSKxnxMXnbgMW2p1DndG5tYcD0tLF0ti0bByVd9LmDFukGc2iLpqZFTdeAeQGtK8xf2zaOrnbbdgtlNfTXrjGYdw79OTmxw7d48ZMn5OV-_jxbBMvVw-PsbhkYEcs2sFZZlJzpITOlMkDUEpJECy2yLFNDSEIUoTSaQWaVkKg1MohlJGKuMzEh1_u9O9d8dujbtCq8wbKEGpvOp1wnkU6UiqNBeruXGtd479CmO1dU4PqUs_QbcbpHnB4QpwfEg_vy51CXDbOD95ep-AKtin52</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1896895576</pqid></control><display><type>article</type><title>Safety and Efficacy of Chloral Hydrate Sedation in Paediatric Sedation for Ophthalmic Procedures</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Chan, Amy Mh ; Tan, Geok Koon ; Loh, Huey Peng ; Lim, Sock Huang ; Chia, Audrey Wl</creator><creatorcontrib>Chan, Amy Mh ; Tan, Geok Koon ; Loh, Huey Peng ; Lim, Sock Huang ; Chia, Audrey Wl</creatorcontrib><description>Chloral hydrate (CH) sedation is routinely used in paediatric ophthalmic examination in Singapore as an alternative to examination under general anaesthesia. Despite CH's traditionally high success rates and relatively low rate of adverse events, there is little data on its safety and efficacy as a sedative for ophthalmic procedures in an Asian population.
A retrospective chart review was performed, including children who underwent CH sedation at the Singapore National Eye Centre from January 2012 to January 2015. Participants were given an initial dose of CH and a top-up dose if required. Univariate and multivariate analyses were performed on data collected.
CH sedation was successful in 144 of 153 children (94.1%). Of the 20 (13.0%) who required a top-up dose, 4 failed to sedate. The mean sedation onset was 29.4 minutes (SD: 24.3) and mean sedation duration was 56.5 minutes (SD: 24.0), with more than a third lasting more than 1 hour. The age of children, rather than initial dose of CH, was more relevant in determining success of sedation. Children who were >6 years old were 20.3 times more likely to fail sedation than those aged <2 years. During sedation, depression in the heart rate and a transient reduction of oxygen saturation was documented. All children recovered well post-sedation.
CH is a very useful sedative for paediatric ophthalmic procedures, especially in younger children. Children over 4 years old were more likely to fail sedation and require top-up doses. Alternative means of sedation may need to be considered in these cases.</description><identifier>ISSN: 0304-4602</identifier><identifier>EISSN: 0304-4602</identifier><identifier>DOI: 10.47102/annals-acadmedsg.V46N4p138</identifier><identifier>PMID: 28485461</identifier><language>eng</language><publisher>Singapore</publisher><subject>Age Factors ; Child ; Child, Preschool ; Chloral Hydrate - administration & dosage ; Chloral Hydrate - adverse effects ; Chloral Hydrate - therapeutic use ; Conscious Sedation - adverse effects ; Conscious Sedation - methods ; Diagnostic Techniques, Ophthalmological ; Female ; Humans ; Hypnotics and Sedatives - administration & dosage ; Hypnotics and Sedatives - adverse effects ; Hypnotics and Sedatives - therapeutic use ; Infant ; Male ; Retrospective Studies</subject><ispartof>Annals of the Academy of Medicine, Singapore, 2017-04, Vol.46 (4), p.138-144</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-ff5fe4108f5f055baee84a998383bbb53bb92e324c80abf534e88e0a7463718b3</citedby><cites>FETCH-LOGICAL-c374t-ff5fe4108f5f055baee84a998383bbb53bb92e324c80abf534e88e0a7463718b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28485461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, Amy Mh</creatorcontrib><creatorcontrib>Tan, Geok Koon</creatorcontrib><creatorcontrib>Loh, Huey Peng</creatorcontrib><creatorcontrib>Lim, Sock Huang</creatorcontrib><creatorcontrib>Chia, Audrey Wl</creatorcontrib><title>Safety and Efficacy of Chloral Hydrate Sedation in Paediatric Sedation for Ophthalmic Procedures</title><title>Annals of the Academy of Medicine, Singapore</title><addtitle>Ann Acad Med Singapore</addtitle><description>Chloral hydrate (CH) sedation is routinely used in paediatric ophthalmic examination in Singapore as an alternative to examination under general anaesthesia. Despite CH's traditionally high success rates and relatively low rate of adverse events, there is little data on its safety and efficacy as a sedative for ophthalmic procedures in an Asian population.
A retrospective chart review was performed, including children who underwent CH sedation at the Singapore National Eye Centre from January 2012 to January 2015. Participants were given an initial dose of CH and a top-up dose if required. Univariate and multivariate analyses were performed on data collected.
CH sedation was successful in 144 of 153 children (94.1%). Of the 20 (13.0%) who required a top-up dose, 4 failed to sedate. The mean sedation onset was 29.4 minutes (SD: 24.3) and mean sedation duration was 56.5 minutes (SD: 24.0), with more than a third lasting more than 1 hour. The age of children, rather than initial dose of CH, was more relevant in determining success of sedation. Children who were >6 years old were 20.3 times more likely to fail sedation than those aged <2 years. During sedation, depression in the heart rate and a transient reduction of oxygen saturation was documented. All children recovered well post-sedation.
CH is a very useful sedative for paediatric ophthalmic procedures, especially in younger children. Children over 4 years old were more likely to fail sedation and require top-up doses. Alternative means of sedation may need to be considered in these cases.</description><subject>Age Factors</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chloral Hydrate - administration & dosage</subject><subject>Chloral Hydrate - adverse effects</subject><subject>Chloral Hydrate - therapeutic use</subject><subject>Conscious Sedation - adverse effects</subject><subject>Conscious Sedation - methods</subject><subject>Diagnostic Techniques, Ophthalmological</subject><subject>Female</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - administration & dosage</subject><subject>Hypnotics and Sedatives - adverse effects</subject><subject>Hypnotics and Sedatives - therapeutic use</subject><subject>Infant</subject><subject>Male</subject><subject>Retrospective Studies</subject><issn>0304-4602</issn><issn>0304-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1PwzAMhiMEYmPwF1AkLlw6kiZpU3FC02BIE5s04Frc1GFF_RhJe-i_p2IwuNiW_b629RByxdlUxpyFN1DXUPoADOQV5v59-iqjJ7njQh-RMRNMBjJi4fG_ekTOvP9gTMYsjE7JKNRSKxnxMXnbgMW2p1DndG5tYcD0tLF0ti0bByVd9LmDFukGc2iLpqZFTdeAeQGtK8xf2zaOrnbbdgtlNfTXrjGYdw79OTmxw7d48ZMn5OV-_jxbBMvVw-PsbhkYEcs2sFZZlJzpITOlMkDUEpJECy2yLFNDSEIUoTSaQWaVkKg1MohlJGKuMzEh1_u9O9d8dujbtCq8wbKEGpvOp1wnkU6UiqNBeruXGtd479CmO1dU4PqUs_QbcbpHnB4QpwfEg_vy51CXDbOD95ep-AKtin52</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Chan, Amy Mh</creator><creator>Tan, Geok Koon</creator><creator>Loh, Huey Peng</creator><creator>Lim, Sock Huang</creator><creator>Chia, Audrey Wl</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Safety and Efficacy of Chloral Hydrate Sedation in Paediatric Sedation for Ophthalmic Procedures</title><author>Chan, Amy Mh ; Tan, Geok Koon ; Loh, Huey Peng ; Lim, Sock Huang ; Chia, Audrey Wl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-ff5fe4108f5f055baee84a998383bbb53bb92e324c80abf534e88e0a7463718b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age Factors</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chloral Hydrate - administration & dosage</topic><topic>Chloral Hydrate - adverse effects</topic><topic>Chloral Hydrate - therapeutic use</topic><topic>Conscious Sedation - adverse effects</topic><topic>Conscious Sedation - methods</topic><topic>Diagnostic Techniques, Ophthalmological</topic><topic>Female</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - administration & dosage</topic><topic>Hypnotics and Sedatives - adverse effects</topic><topic>Hypnotics and Sedatives - therapeutic use</topic><topic>Infant</topic><topic>Male</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Amy Mh</creatorcontrib><creatorcontrib>Tan, Geok Koon</creatorcontrib><creatorcontrib>Loh, Huey Peng</creatorcontrib><creatorcontrib>Lim, Sock Huang</creatorcontrib><creatorcontrib>Chia, Audrey Wl</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the Academy of Medicine, Singapore</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Amy Mh</au><au>Tan, Geok Koon</au><au>Loh, Huey Peng</au><au>Lim, Sock Huang</au><au>Chia, Audrey Wl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and Efficacy of Chloral Hydrate Sedation in Paediatric Sedation for Ophthalmic Procedures</atitle><jtitle>Annals of the Academy of Medicine, Singapore</jtitle><addtitle>Ann Acad Med Singapore</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>46</volume><issue>4</issue><spage>138</spage><epage>144</epage><pages>138-144</pages><issn>0304-4602</issn><eissn>0304-4602</eissn><abstract>Chloral hydrate (CH) sedation is routinely used in paediatric ophthalmic examination in Singapore as an alternative to examination under general anaesthesia. Despite CH's traditionally high success rates and relatively low rate of adverse events, there is little data on its safety and efficacy as a sedative for ophthalmic procedures in an Asian population.
A retrospective chart review was performed, including children who underwent CH sedation at the Singapore National Eye Centre from January 2012 to January 2015. Participants were given an initial dose of CH and a top-up dose if required. Univariate and multivariate analyses were performed on data collected.
CH sedation was successful in 144 of 153 children (94.1%). Of the 20 (13.0%) who required a top-up dose, 4 failed to sedate. The mean sedation onset was 29.4 minutes (SD: 24.3) and mean sedation duration was 56.5 minutes (SD: 24.0), with more than a third lasting more than 1 hour. The age of children, rather than initial dose of CH, was more relevant in determining success of sedation. Children who were >6 years old were 20.3 times more likely to fail sedation than those aged <2 years. During sedation, depression in the heart rate and a transient reduction of oxygen saturation was documented. All children recovered well post-sedation.
CH is a very useful sedative for paediatric ophthalmic procedures, especially in younger children. Children over 4 years old were more likely to fail sedation and require top-up doses. Alternative means of sedation may need to be considered in these cases.</abstract><cop>Singapore</cop><pmid>28485461</pmid><doi>10.47102/annals-acadmedsg.V46N4p138</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-4602 |
| ispartof | Annals of the Academy of Medicine, Singapore, 2017-04, Vol.46 (4), p.138-144 |
| issn | 0304-4602 0304-4602 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1896895576 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Age Factors Child Child, Preschool Chloral Hydrate - administration & dosage Chloral Hydrate - adverse effects Chloral Hydrate - therapeutic use Conscious Sedation - adverse effects Conscious Sedation - methods Diagnostic Techniques, Ophthalmological Female Humans Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - adverse effects Hypnotics and Sedatives - therapeutic use Infant Male Retrospective Studies |
| title | Safety and Efficacy of Chloral Hydrate Sedation in Paediatric Sedation for Ophthalmic Procedures |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T06%3A51%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Safety%20and%20Efficacy%20of%20Chloral%20Hydrate%20Sedation%20in%20Paediatric%20Sedation%20for%20Ophthalmic%20Procedures&rft.jtitle=Annals%20of%20the%20Academy%20of%20Medicine,%20Singapore&rft.au=Chan,%20Amy%20Mh&rft.date=2017-04-01&rft.volume=46&rft.issue=4&rft.spage=138&rft.epage=144&rft.pages=138-144&rft.issn=0304-4602&rft.eissn=0304-4602&rft_id=info:doi/10.47102/annals-acadmedsg.V46N4p138&rft_dat=%3Cproquest_cross%3E1896895576%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1896895576&rft_id=info:pmid/28485461&rfr_iscdi=true |