From mouse to pig: Is PRV vaccine safe across two species?

•Bartha-K61 PRV vaccine was proved to be highly pathogenic to mice by propagation in vivo for five continuous passages.•There was no safety concern of Bartha-K61 PRV vaccine on pigs after the vaccine virus was passaged in mice for 5 times.•The safety of 5th mouse-derived PRV on pigs may suggest mice...

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Veröffentlicht in:	Virus research 2017-05, Vol.236, p.44-49
Hauptverfasser:	Li, Yufang, Yan, Shijun, Li, Xuefeng, Yang, Qingyuan, Guo, Linghua, Wang, Yuzhou, Xiao, Yan, Tan, Feifei, Li, Xiangdong, Tian, Kegong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - immunology Cross-species Herpesvirus 1, Suid - genetics Herpesvirus 1, Suid - immunology Herpesvirus 1, Suid - pathogenicity Mice Mice, Inbred BALB C Pseudorabies - prevention & control Pseudorabies - virology Pseudorabies Vaccines - administration & dosage Pseudorabies Vaccines - adverse effects Pseudorabies virus Serial Passage Species Specificity Sus scrofa Swine Swine Diseases - immunology Swine Diseases - prevention & control Swine Diseases - virology Vaccine safety Virulence
Online-Zugang:	Volltext
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