Micronutrient Therapy for Violent and Aggressive Male Youth: An Open-Label Trial
Pharmacotherapy for problematic aggressive and violent behavior disorders in male children and adolescents is associated with significant adverse events. Treatments with more acceptable risk-benefit ratios are critically needed. Micronutrient intervention will be investigated as an alternative to br...
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| Veröffentlicht in: | Journal of child and adolescent psychopharmacology 2017-11, Vol.27 (9), p.823-832 |
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| creator | Hambly, Jessica L Francis, Kelly Khan, Sohil Gibbons, Kristen S Walsh, William J Lambert, Brett Testa, Chris Haywood, Alison |
| description | Pharmacotherapy for problematic aggressive and violent behavior disorders in male children and adolescents is associated with significant adverse events. Treatments with more acceptable risk-benefit ratios are critically needed. Micronutrient intervention will be investigated as an alternative to bridge the therapeutic gap in the management of these behaviors.
Males aged 4-14 who displayed ongoing violent and aggressive behaviors received micronutrient intervention containing alpha-tocopherol (vitamin E), ascorbic acid (vitamin C), biotin, chromium, pyridoxal-5-phosphate (P5P), pyridoxine (vitamins B6), selenium, and zinc, in a 16-week open-label trial. Plasma zinc, plasma copper, copper/zinc ratio, and urinary hydroxyhemopyrroline-2-one (HPL) tests were conducted at baseline and endpoint. Participants were examined for changes in aggressive and violent behaviors measured using the Children's Aggression Scale (CAS) and the Modified Overt Aggression Scale (MOAS), improvements in family functioning measured using the Family Functioning Style Scale, improvements in health-related quality of life (HRQoL) measured using the Pediatric Quality of Life Inventory (PedsQL) at baseline, 8 weeks, endpoint, and at 4-6-month follow-up.
Thirty-two male children and adolescents met inclusion criteria. Thirty-one (mean 8.35 ± standard deviation 2.93 years) completed the study, with one participant lost to follow-up. Micronutrient therapy significantly improved parent-reported aggressive and violent behaviors measured using the CAS for all domains except the use of weapons (p |
| doi_str_mv | 10.1089/cap.2016.0199 |
| format | Article |
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Males aged 4-14 who displayed ongoing violent and aggressive behaviors received micronutrient intervention containing alpha-tocopherol (vitamin E), ascorbic acid (vitamin C), biotin, chromium, pyridoxal-5-phosphate (P5P), pyridoxine (vitamins B6), selenium, and zinc, in a 16-week open-label trial. Plasma zinc, plasma copper, copper/zinc ratio, and urinary hydroxyhemopyrroline-2-one (HPL) tests were conducted at baseline and endpoint. Participants were examined for changes in aggressive and violent behaviors measured using the Children's Aggression Scale (CAS) and the Modified Overt Aggression Scale (MOAS), improvements in family functioning measured using the Family Functioning Style Scale, improvements in health-related quality of life (HRQoL) measured using the Pediatric Quality of Life Inventory (PedsQL) at baseline, 8 weeks, endpoint, and at 4-6-month follow-up.
Thirty-two male children and adolescents met inclusion criteria. Thirty-one (mean 8.35 ± standard deviation 2.93 years) completed the study, with one participant lost to follow-up. Micronutrient therapy significantly improved parent-reported aggressive and violent behaviors measured using the CAS for all domains except the use of weapons (p < 0.001 to p = 0.02) with medium to large effect size (Cohen's d = 0.72-1.43) and the MOAS (p < 0.001) with large effect size (Cohen's d = 1.26). Parent-reported HRQoL (p < 0.001; Cohen's d = -1.69) and family functioning (p = 0.03; Cohen's d = -0.41) also significantly improved.
Micronutrient therapy appeared well tolerated, with a favorable side effect profile. It appeared effective in the reduction of parent-reported aggressive and violent behaviors, and showed improvement in family functioning and HRQoL in male youth after 16 weeks. Further research in the form of a double-blinded, randomized controlled trial is required to verify these initial positive observations.</description><identifier>ISSN: 1044-5463</identifier><identifier>EISSN: 1557-8992</identifier><identifier>DOI: 10.1089/cap.2016.0199</identifier><identifier>PMID: 28481642</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adolescents ; Aggression ; Aggression - drug effects ; Aggressive behavior ; Aggressiveness ; Ascorbic acid ; Behavior ; Biotin ; Child ; Children ; Chromium ; Clinical outcomes ; Clinical trials ; Copper ; Family - psychology ; Female ; Humans ; Juvenile delinquency ; Male ; Males ; Mental disorders ; Mental Disorders - diagnosis ; Mental Disorders - psychology ; Metabolism ; Micronutrients - therapeutic use ; Oxidative stress ; Pediatrics ; Phosphates ; Psychopharmacology ; Pyridoxine ; Quality of life ; Quality of Life - psychology ; Selenium ; Surveys and Questionnaires ; Violence ; Violence - prevention & control ; Vitamin B6 ; Vitamin C ; Vitamin E ; Vitamins ; Zinc</subject><ispartof>Journal of child and adolescent psychopharmacology, 2017-11, Vol.27 (9), p.823-832</ispartof><rights>(©) Copyright 2017, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-b7e6d7ea981c9f4669e038d970ba2c3db6c6d30ed701a3365933534b7ca560d83</citedby><cites>FETCH-LOGICAL-c321t-b7e6d7ea981c9f4669e038d970ba2c3db6c6d30ed701a3365933534b7ca560d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28481642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hambly, Jessica L</creatorcontrib><creatorcontrib>Francis, Kelly</creatorcontrib><creatorcontrib>Khan, Sohil</creatorcontrib><creatorcontrib>Gibbons, Kristen S</creatorcontrib><creatorcontrib>Walsh, William J</creatorcontrib><creatorcontrib>Lambert, Brett</creatorcontrib><creatorcontrib>Testa, Chris</creatorcontrib><creatorcontrib>Haywood, Alison</creatorcontrib><title>Micronutrient Therapy for Violent and Aggressive Male Youth: An Open-Label Trial</title><title>Journal of child and adolescent psychopharmacology</title><addtitle>J Child Adolesc Psychopharmacol</addtitle><description>Pharmacotherapy for problematic aggressive and violent behavior disorders in male children and adolescents is associated with significant adverse events. Treatments with more acceptable risk-benefit ratios are critically needed. Micronutrient intervention will be investigated as an alternative to bridge the therapeutic gap in the management of these behaviors.
Males aged 4-14 who displayed ongoing violent and aggressive behaviors received micronutrient intervention containing alpha-tocopherol (vitamin E), ascorbic acid (vitamin C), biotin, chromium, pyridoxal-5-phosphate (P5P), pyridoxine (vitamins B6), selenium, and zinc, in a 16-week open-label trial. Plasma zinc, plasma copper, copper/zinc ratio, and urinary hydroxyhemopyrroline-2-one (HPL) tests were conducted at baseline and endpoint. Participants were examined for changes in aggressive and violent behaviors measured using the Children's Aggression Scale (CAS) and the Modified Overt Aggression Scale (MOAS), improvements in family functioning measured using the Family Functioning Style Scale, improvements in health-related quality of life (HRQoL) measured using the Pediatric Quality of Life Inventory (PedsQL) at baseline, 8 weeks, endpoint, and at 4-6-month follow-up.
Thirty-two male children and adolescents met inclusion criteria. Thirty-one (mean 8.35 ± standard deviation 2.93 years) completed the study, with one participant lost to follow-up. Micronutrient therapy significantly improved parent-reported aggressive and violent behaviors measured using the CAS for all domains except the use of weapons (p < 0.001 to p = 0.02) with medium to large effect size (Cohen's d = 0.72-1.43) and the MOAS (p < 0.001) with large effect size (Cohen's d = 1.26). Parent-reported HRQoL (p < 0.001; Cohen's d = -1.69) and family functioning (p = 0.03; Cohen's d = -0.41) also significantly improved.
Micronutrient therapy appeared well tolerated, with a favorable side effect profile. It appeared effective in the reduction of parent-reported aggressive and violent behaviors, and showed improvement in family functioning and HRQoL in male youth after 16 weeks. Further research in the form of a double-blinded, randomized controlled trial is required to verify these initial positive observations.</description><subject>Adolescents</subject><subject>Aggression</subject><subject>Aggression - drug effects</subject><subject>Aggressive behavior</subject><subject>Aggressiveness</subject><subject>Ascorbic acid</subject><subject>Behavior</subject><subject>Biotin</subject><subject>Child</subject><subject>Children</subject><subject>Chromium</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Copper</subject><subject>Family - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Juvenile delinquency</subject><subject>Male</subject><subject>Males</subject><subject>Mental disorders</subject><subject>Mental Disorders - diagnosis</subject><subject>Mental Disorders - psychology</subject><subject>Metabolism</subject><subject>Micronutrients - therapeutic use</subject><subject>Oxidative stress</subject><subject>Pediatrics</subject><subject>Phosphates</subject><subject>Psychopharmacology</subject><subject>Pyridoxine</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Selenium</subject><subject>Surveys and Questionnaires</subject><subject>Violence</subject><subject>Violence - prevention & control</subject><subject>Vitamin B6</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><subject>Vitamins</subject><subject>Zinc</subject><issn>1044-5463</issn><issn>1557-8992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkM1LwzAYxoMobk6PXiXgxUtn0rT58DaGX7AxD1PwFNLk3dbRtTVphf33tmx68PQ8vPx4ePkhdE3JmBKp7q2pxzGhfEyoUidoSNNURFKp-LTrJEmiNOFsgC5C2BJCGSf8HA1imUjKk3iI3ua59VXZNj6HssHLDXhT7_Gq8vgjr4r-ZkqHJ-u1hxDyb8BzUwD-rNpm84AnJV7UUEYzk0GBlz43xSU6W5kiwNUxR-j96XE5fYlmi-fX6WQWWRbTJsoEcCfAKEmtWiWcKyBMOiVIZmLLXMYtd4yAE4QaxniqGEtZkglrUk6cZCN0d9itffXVQmj0Lg8WisKUULVBU6m4VIRS0aG3_9Bt1fqy-05TxRkVKu5ihKID1fkIwcNK1z7fGb_XlOhete5U61617lV3_M1xtc124P7oX7fsBzqKd_Q</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Hambly, Jessica L</creator><creator>Francis, Kelly</creator><creator>Khan, Sohil</creator><creator>Gibbons, Kristen S</creator><creator>Walsh, William J</creator><creator>Lambert, Brett</creator><creator>Testa, Chris</creator><creator>Haywood, Alison</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201711</creationdate><title>Micronutrient Therapy for Violent and Aggressive Male Youth: An Open-Label Trial</title><author>Hambly, Jessica L ; Francis, Kelly ; Khan, Sohil ; Gibbons, Kristen S ; Walsh, William J ; Lambert, Brett ; Testa, Chris ; Haywood, Alison</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-b7e6d7ea981c9f4669e038d970ba2c3db6c6d30ed701a3365933534b7ca560d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescents</topic><topic>Aggression</topic><topic>Aggression - drug effects</topic><topic>Aggressive behavior</topic><topic>Aggressiveness</topic><topic>Ascorbic acid</topic><topic>Behavior</topic><topic>Biotin</topic><topic>Child</topic><topic>Children</topic><topic>Chromium</topic><topic>Clinical outcomes</topic><topic>Clinical trials</topic><topic>Copper</topic><topic>Family - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Juvenile delinquency</topic><topic>Male</topic><topic>Males</topic><topic>Mental disorders</topic><topic>Mental Disorders - diagnosis</topic><topic>Mental Disorders - psychology</topic><topic>Metabolism</topic><topic>Micronutrients - therapeutic use</topic><topic>Oxidative stress</topic><topic>Pediatrics</topic><topic>Phosphates</topic><topic>Psychopharmacology</topic><topic>Pyridoxine</topic><topic>Quality of life</topic><topic>Quality of Life - psychology</topic><topic>Selenium</topic><topic>Surveys and Questionnaires</topic><topic>Violence</topic><topic>Violence - prevention & control</topic><topic>Vitamin B6</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><topic>Vitamins</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hambly, Jessica L</creatorcontrib><creatorcontrib>Francis, Kelly</creatorcontrib><creatorcontrib>Khan, Sohil</creatorcontrib><creatorcontrib>Gibbons, Kristen S</creatorcontrib><creatorcontrib>Walsh, William J</creatorcontrib><creatorcontrib>Lambert, Brett</creatorcontrib><creatorcontrib>Testa, Chris</creatorcontrib><creatorcontrib>Haywood, Alison</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of child and adolescent psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hambly, Jessica L</au><au>Francis, Kelly</au><au>Khan, Sohil</au><au>Gibbons, Kristen S</au><au>Walsh, William J</au><au>Lambert, Brett</au><au>Testa, Chris</au><au>Haywood, Alison</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micronutrient Therapy for Violent and Aggressive Male Youth: An Open-Label Trial</atitle><jtitle>Journal of child and adolescent psychopharmacology</jtitle><addtitle>J Child Adolesc Psychopharmacol</addtitle><date>2017-11</date><risdate>2017</risdate><volume>27</volume><issue>9</issue><spage>823</spage><epage>832</epage><pages>823-832</pages><issn>1044-5463</issn><eissn>1557-8992</eissn><abstract>Pharmacotherapy for problematic aggressive and violent behavior disorders in male children and adolescents is associated with significant adverse events. Treatments with more acceptable risk-benefit ratios are critically needed. Micronutrient intervention will be investigated as an alternative to bridge the therapeutic gap in the management of these behaviors.
Males aged 4-14 who displayed ongoing violent and aggressive behaviors received micronutrient intervention containing alpha-tocopherol (vitamin E), ascorbic acid (vitamin C), biotin, chromium, pyridoxal-5-phosphate (P5P), pyridoxine (vitamins B6), selenium, and zinc, in a 16-week open-label trial. Plasma zinc, plasma copper, copper/zinc ratio, and urinary hydroxyhemopyrroline-2-one (HPL) tests were conducted at baseline and endpoint. Participants were examined for changes in aggressive and violent behaviors measured using the Children's Aggression Scale (CAS) and the Modified Overt Aggression Scale (MOAS), improvements in family functioning measured using the Family Functioning Style Scale, improvements in health-related quality of life (HRQoL) measured using the Pediatric Quality of Life Inventory (PedsQL) at baseline, 8 weeks, endpoint, and at 4-6-month follow-up.
Thirty-two male children and adolescents met inclusion criteria. Thirty-one (mean 8.35 ± standard deviation 2.93 years) completed the study, with one participant lost to follow-up. Micronutrient therapy significantly improved parent-reported aggressive and violent behaviors measured using the CAS for all domains except the use of weapons (p < 0.001 to p = 0.02) with medium to large effect size (Cohen's d = 0.72-1.43) and the MOAS (p < 0.001) with large effect size (Cohen's d = 1.26). Parent-reported HRQoL (p < 0.001; Cohen's d = -1.69) and family functioning (p = 0.03; Cohen's d = -0.41) also significantly improved.
Micronutrient therapy appeared well tolerated, with a favorable side effect profile. It appeared effective in the reduction of parent-reported aggressive and violent behaviors, and showed improvement in family functioning and HRQoL in male youth after 16 weeks. Further research in the form of a double-blinded, randomized controlled trial is required to verify these initial positive observations.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>28481642</pmid><doi>10.1089/cap.2016.0199</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of child and adolescent psychopharmacology, 2017-11, Vol.27 (9), p.823-832 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescents Aggression Aggression - drug effects Aggressive behavior Aggressiveness Ascorbic acid Behavior Biotin Child Children Chromium Clinical outcomes Clinical trials Copper Family - psychology Female Humans Juvenile delinquency Male Males Mental disorders Mental Disorders - diagnosis Mental Disorders - psychology Metabolism Micronutrients - therapeutic use Oxidative stress Pediatrics Phosphates Psychopharmacology Pyridoxine Quality of life Quality of Life - psychology Selenium Surveys and Questionnaires Violence Violence - prevention & control Vitamin B6 Vitamin C Vitamin E Vitamins Zinc |
| title | Micronutrient Therapy for Violent and Aggressive Male Youth: An Open-Label Trial |
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