The Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates Radiation-Induced Lung Injury in a Mouse Model

Radiation-induced lung injury (RILI) is a potentially life-threatening complication of radiotherapy. In the current study, we examined the potential protective effects of URB937, an inhibitor of fatty acid amide hydrolase using a mouse model of RILI. Briefly, male C57BL/6 mice received 16Gy irradiat...

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Veröffentlicht in:	Inflammation 2017-08, Vol.40 (4), p.1254-1263
Hauptverfasser:	Li, Rui, Chen, Guo, Zhou, Lin, Xu, He, Tang, Fei, Lan, Jie, Tong, Ruizhan, Deng, Lei, Xue, Jianxin, Lu, You
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Amidohydrolases - antagonists & inhibitors Animals Biomedical and Life Sciences Biomedicine Bronchus Cannabinoids Cannabinoids - pharmacology Cannabinoids - therapeutic use Cytokines Fatty acids Fatty-acid amide hydrolase Hydrolase Immunology Inflammation Inflammation - drug therapy Inflammation - prevention & control Injection Interleukin 1 Interleukin 6 Internal Medicine Leukocyte migration Lipid peroxidation Lung carcinoma Lung Injury - drug therapy Lung Injury - etiology Lung Injury - pathology Lung Injury - prevention & control Male Mice Mice, Inbred C57BL Original Article Pathology Pharmacology/Toxicology Pulmonary fibrosis Radiation therapy Radiation-Protective Agents - therapeutic use Radiotherapy - adverse effects Rheumatology Rodents Survival Thorax Thorax - drug effects Thorax - radiation effects Tumor Burden - drug effects Tumor necrosis factor
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