Methylglyoxal-Induced Protection Response and Toxicity: Role of Glutathione Reductase and Thioredoxin Systems

Thioredoxin (Trx) and glyoxalase (Glo) systems have been suggested to be molecular targets of methylglyoxal (MGO). This highly reactive endogenous compound has been associated with the development of neurodegenerative pathologies and cell death. In the present study, the glutathione (GSH), Trx, and...

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Veröffentlicht in:	Neurotoxicity research 2017-10, Vol.32 (3), p.340-350
Hauptverfasser:	Schmitz, Ariana Ern, de Souza, Luiz Felipe, dos Santos, Barbara, Maher, Pamela, Lopes, Fernanda Martins, Londero, Giovana Ferreira, Klamt, Fabio, Dafre, Alcir Luiz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell Line Cell Survival - physiology Dose-Response Relationship, Drug Female Glutathione - metabolism Glutathione Reductase - metabolism Hippocampus - enzymology Humans Mice Neurobiology Neurochemistry Neurology Neurons - enzymology Neuroprotection - physiology Neurosciences Original Article Pharmacology/Toxicology Pyruvaldehyde - metabolism Pyruvaldehyde - toxicity Thioredoxin-Disulfide Reductase - metabolism Thioredoxins - metabolism Tissue Culture Techniques
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