Angelica gigas Nakai extract-loaded fast-dissolving nanofiber based on poly(vinyl alcohol) and Soluplus for oral cancer therapy
[Display omitted] A poly(vinyl alcohol) (PVA) and Soluplus (SP)-based nanofiber (NF) mat was fabricated using an electrospinning method for the delivery of Angelica gigas Nakai (AGN) extract (ext) to oral cancers. AGN/SP NF (mean diameter: 75±26nm; entrapment efficiency: 84.6±18.6%) and AGN/PVA/SP N...
Gespeichert in:
| Veröffentlicht in: | International journal of pharmaceutics 2017-06, Vol.526 (1-2), p.225-234 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 234 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 225 |
| container_title | International journal of pharmaceutics |
| container_volume | 526 |
| creator | Nam, Suyeong Lee, Jeong-Jun Lee, Song Yi Jeong, Jae Young Kang, Wie-Soo Cho, Hyun-Jong |
| description | [Display omitted]
A poly(vinyl alcohol) (PVA) and Soluplus (SP)-based nanofiber (NF) mat was fabricated using an electrospinning method for the delivery of Angelica gigas Nakai (AGN) extract (ext) to oral cancers. AGN/SP NF (mean diameter: 75±26nm; entrapment efficiency: 84.6±18.6%) and AGN/PVA/SP NF (mean diameter: 170±35nm; entrapment efficiency: 81.0±10.1%) were fabricated using an electrospinning method. Amorphization of AGN EtOH ext was verified by X-ray diffractometry (XRD) analysis during the electrospinning process for the fabrication of NF structures. The AGN/PVA/SP NF group exhibited instant wetting (within 2s) and rapid disintegration (within 3min) properties compared with those in the AGN/PVA NF group, assuring the successful and conventional application of AGN/PVA/SP NF film in the oral cavity without the intake of beverages. After the spontaneous dispersion of NF in the aqueous media, it was converted to nanoparticles with a narrow size distribution. In YD-9 cells (oral squamous cell carcinoma from buccal cheek), the anti-proliferation activity was ordered as follows: AGN EtOH ext suspension < AGN/PVA NF < AGN/PVA/SP NF. All of these findings indicated that AGN/PVA/SP NF can be used as a fast-dissolving mat formulation for the therapy of oral cancers. |
| doi_str_mv | 10.1016/j.ijpharm.2017.05.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1896415997</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378517317303964</els_id><sourcerecordid>1896415997</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-aada0fa8583bf715df9f07ada2058e63f50a6b72a13e29223a0ffc7dff9e35e63</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi1ERbeFnwDysRyS-mMdOydUVVCQKnoAztbEH7tevHGwk4o99a_jaheunEaaed4ZzYPQW0paSmh3vWvDbtpC3reMUNkS0RKyfoFWVEne8LXsXqIV4VI1gkp-ji5K2RFCOkb5K3TO1FoqJtUKPd2MGxeDAbwJGyj4K_yEgN3vOYOZm5jAOos9lLmxoZQUH8O4wSOMyYfBZTxAqfM04inFw1UdHiKGaNI2xfcYRou_pbhMcSnYp4xThogNjKYm563LMB1eozMPsbg3p3qJfnz6-P32c3P_cPfl9ua-MbwTcwNggXhQQvHBSyqs7z2RtcmIUK7jXhDoBsmAcsd6xnilvZHW-95xUYFLdHXcO-X0a3Fl1vtQjIsRRpeWoqnquzUVfS8rKo6oyamU7LyecthDPmhK9LN7vdMn9_rZvSZCV_c19-50Yhn2zv5L_ZVdgQ9HwNVHH4PLupjgqg0bsjOztin858QfyxKbBw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1896415997</pqid></control><display><type>article</type><title>Angelica gigas Nakai extract-loaded fast-dissolving nanofiber based on poly(vinyl alcohol) and Soluplus for oral cancer therapy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Nam, Suyeong ; Lee, Jeong-Jun ; Lee, Song Yi ; Jeong, Jae Young ; Kang, Wie-Soo ; Cho, Hyun-Jong</creator><creatorcontrib>Nam, Suyeong ; Lee, Jeong-Jun ; Lee, Song Yi ; Jeong, Jae Young ; Kang, Wie-Soo ; Cho, Hyun-Jong</creatorcontrib><description>[Display omitted]
A poly(vinyl alcohol) (PVA) and Soluplus (SP)-based nanofiber (NF) mat was fabricated using an electrospinning method for the delivery of Angelica gigas Nakai (AGN) extract (ext) to oral cancers. AGN/SP NF (mean diameter: 75±26nm; entrapment efficiency: 84.6±18.6%) and AGN/PVA/SP NF (mean diameter: 170±35nm; entrapment efficiency: 81.0±10.1%) were fabricated using an electrospinning method. Amorphization of AGN EtOH ext was verified by X-ray diffractometry (XRD) analysis during the electrospinning process for the fabrication of NF structures. The AGN/PVA/SP NF group exhibited instant wetting (within 2s) and rapid disintegration (within 3min) properties compared with those in the AGN/PVA NF group, assuring the successful and conventional application of AGN/PVA/SP NF film in the oral cavity without the intake of beverages. After the spontaneous dispersion of NF in the aqueous media, it was converted to nanoparticles with a narrow size distribution. In YD-9 cells (oral squamous cell carcinoma from buccal cheek), the anti-proliferation activity was ordered as follows: AGN EtOH ext suspension < AGN/PVA NF < AGN/PVA/SP NF. All of these findings indicated that AGN/PVA/SP NF can be used as a fast-dissolving mat formulation for the therapy of oral cancers.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2017.05.004</identifier><identifier>PMID: 28478278</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Angelica - chemistry ; Angelica gigas Nakai ; Anti-proliferation ; Cell Line, Tumor ; Drug Carriers - chemistry ; Electrospinning ; Fast-dissolving mat ; Humans ; Mouth Neoplasms - drug therapy ; Nanofiber ; Nanofibers - chemistry ; Oral cancer ; Plant Extracts - pharmacology ; Polyethylene Glycols - chemistry ; Polyvinyl Alcohol - chemistry ; Polyvinyls - chemistry</subject><ispartof>International journal of pharmaceutics, 2017-06, Vol.526 (1-2), p.225-234</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-aada0fa8583bf715df9f07ada2058e63f50a6b72a13e29223a0ffc7dff9e35e63</citedby><cites>FETCH-LOGICAL-c365t-aada0fa8583bf715df9f07ada2058e63f50a6b72a13e29223a0ffc7dff9e35e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517317303964$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28478278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nam, Suyeong</creatorcontrib><creatorcontrib>Lee, Jeong-Jun</creatorcontrib><creatorcontrib>Lee, Song Yi</creatorcontrib><creatorcontrib>Jeong, Jae Young</creatorcontrib><creatorcontrib>Kang, Wie-Soo</creatorcontrib><creatorcontrib>Cho, Hyun-Jong</creatorcontrib><title>Angelica gigas Nakai extract-loaded fast-dissolving nanofiber based on poly(vinyl alcohol) and Soluplus for oral cancer therapy</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
A poly(vinyl alcohol) (PVA) and Soluplus (SP)-based nanofiber (NF) mat was fabricated using an electrospinning method for the delivery of Angelica gigas Nakai (AGN) extract (ext) to oral cancers. AGN/SP NF (mean diameter: 75±26nm; entrapment efficiency: 84.6±18.6%) and AGN/PVA/SP NF (mean diameter: 170±35nm; entrapment efficiency: 81.0±10.1%) were fabricated using an electrospinning method. Amorphization of AGN EtOH ext was verified by X-ray diffractometry (XRD) analysis during the electrospinning process for the fabrication of NF structures. The AGN/PVA/SP NF group exhibited instant wetting (within 2s) and rapid disintegration (within 3min) properties compared with those in the AGN/PVA NF group, assuring the successful and conventional application of AGN/PVA/SP NF film in the oral cavity without the intake of beverages. After the spontaneous dispersion of NF in the aqueous media, it was converted to nanoparticles with a narrow size distribution. In YD-9 cells (oral squamous cell carcinoma from buccal cheek), the anti-proliferation activity was ordered as follows: AGN EtOH ext suspension < AGN/PVA NF < AGN/PVA/SP NF. All of these findings indicated that AGN/PVA/SP NF can be used as a fast-dissolving mat formulation for the therapy of oral cancers.</description><subject>Angelica - chemistry</subject><subject>Angelica gigas Nakai</subject><subject>Anti-proliferation</subject><subject>Cell Line, Tumor</subject><subject>Drug Carriers - chemistry</subject><subject>Electrospinning</subject><subject>Fast-dissolving mat</subject><subject>Humans</subject><subject>Mouth Neoplasms - drug therapy</subject><subject>Nanofiber</subject><subject>Nanofibers - chemistry</subject><subject>Oral cancer</subject><subject>Plant Extracts - pharmacology</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>Polyvinyls - chemistry</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1ERbeFnwDysRyS-mMdOydUVVCQKnoAztbEH7tevHGwk4o99a_jaheunEaaed4ZzYPQW0paSmh3vWvDbtpC3reMUNkS0RKyfoFWVEne8LXsXqIV4VI1gkp-ji5K2RFCOkb5K3TO1FoqJtUKPd2MGxeDAbwJGyj4K_yEgN3vOYOZm5jAOos9lLmxoZQUH8O4wSOMyYfBZTxAqfM04inFw1UdHiKGaNI2xfcYRou_pbhMcSnYp4xThogNjKYm563LMB1eozMPsbg3p3qJfnz6-P32c3P_cPfl9ua-MbwTcwNggXhQQvHBSyqs7z2RtcmIUK7jXhDoBsmAcsd6xnilvZHW-95xUYFLdHXcO-X0a3Fl1vtQjIsRRpeWoqnquzUVfS8rKo6oyamU7LyecthDPmhK9LN7vdMn9_rZvSZCV_c19-50Yhn2zv5L_ZVdgQ9HwNVHH4PLupjgqg0bsjOztin858QfyxKbBw</recordid><startdate>20170630</startdate><enddate>20170630</enddate><creator>Nam, Suyeong</creator><creator>Lee, Jeong-Jun</creator><creator>Lee, Song Yi</creator><creator>Jeong, Jae Young</creator><creator>Kang, Wie-Soo</creator><creator>Cho, Hyun-Jong</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170630</creationdate><title>Angelica gigas Nakai extract-loaded fast-dissolving nanofiber based on poly(vinyl alcohol) and Soluplus for oral cancer therapy</title><author>Nam, Suyeong ; Lee, Jeong-Jun ; Lee, Song Yi ; Jeong, Jae Young ; Kang, Wie-Soo ; Cho, Hyun-Jong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-aada0fa8583bf715df9f07ada2058e63f50a6b72a13e29223a0ffc7dff9e35e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Angelica - chemistry</topic><topic>Angelica gigas Nakai</topic><topic>Anti-proliferation</topic><topic>Cell Line, Tumor</topic><topic>Drug Carriers - chemistry</topic><topic>Electrospinning</topic><topic>Fast-dissolving mat</topic><topic>Humans</topic><topic>Mouth Neoplasms - drug therapy</topic><topic>Nanofiber</topic><topic>Nanofibers - chemistry</topic><topic>Oral cancer</topic><topic>Plant Extracts - pharmacology</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyvinyl Alcohol - chemistry</topic><topic>Polyvinyls - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nam, Suyeong</creatorcontrib><creatorcontrib>Lee, Jeong-Jun</creatorcontrib><creatorcontrib>Lee, Song Yi</creatorcontrib><creatorcontrib>Jeong, Jae Young</creatorcontrib><creatorcontrib>Kang, Wie-Soo</creatorcontrib><creatorcontrib>Cho, Hyun-Jong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nam, Suyeong</au><au>Lee, Jeong-Jun</au><au>Lee, Song Yi</au><au>Jeong, Jae Young</au><au>Kang, Wie-Soo</au><au>Cho, Hyun-Jong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angelica gigas Nakai extract-loaded fast-dissolving nanofiber based on poly(vinyl alcohol) and Soluplus for oral cancer therapy</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2017-06-30</date><risdate>2017</risdate><volume>526</volume><issue>1-2</issue><spage>225</spage><epage>234</epage><pages>225-234</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
A poly(vinyl alcohol) (PVA) and Soluplus (SP)-based nanofiber (NF) mat was fabricated using an electrospinning method for the delivery of Angelica gigas Nakai (AGN) extract (ext) to oral cancers. AGN/SP NF (mean diameter: 75±26nm; entrapment efficiency: 84.6±18.6%) and AGN/PVA/SP NF (mean diameter: 170±35nm; entrapment efficiency: 81.0±10.1%) were fabricated using an electrospinning method. Amorphization of AGN EtOH ext was verified by X-ray diffractometry (XRD) analysis during the electrospinning process for the fabrication of NF structures. The AGN/PVA/SP NF group exhibited instant wetting (within 2s) and rapid disintegration (within 3min) properties compared with those in the AGN/PVA NF group, assuring the successful and conventional application of AGN/PVA/SP NF film in the oral cavity without the intake of beverages. After the spontaneous dispersion of NF in the aqueous media, it was converted to nanoparticles with a narrow size distribution. In YD-9 cells (oral squamous cell carcinoma from buccal cheek), the anti-proliferation activity was ordered as follows: AGN EtOH ext suspension < AGN/PVA NF < AGN/PVA/SP NF. All of these findings indicated that AGN/PVA/SP NF can be used as a fast-dissolving mat formulation for the therapy of oral cancers.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28478278</pmid><doi>10.1016/j.ijpharm.2017.05.004</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2017-06, Vol.526 (1-2), p.225-234 |
| issn | 0378-5173 1873-3476 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1896415997 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Angelica - chemistry Angelica gigas Nakai Anti-proliferation Cell Line, Tumor Drug Carriers - chemistry Electrospinning Fast-dissolving mat Humans Mouth Neoplasms - drug therapy Nanofiber Nanofibers - chemistry Oral cancer Plant Extracts - pharmacology Polyethylene Glycols - chemistry Polyvinyl Alcohol - chemistry Polyvinyls - chemistry |
| title | Angelica gigas Nakai extract-loaded fast-dissolving nanofiber based on poly(vinyl alcohol) and Soluplus for oral cancer therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T15%3A32%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Angelica%20gigas%20Nakai%20extract-loaded%20fast-dissolving%20nanofiber%20based%20on%20poly(vinyl%20alcohol)%20and%20Soluplus%20for%20oral%20cancer%20therapy&rft.jtitle=International%20journal%20of%20pharmaceutics&rft.au=Nam,%20Suyeong&rft.date=2017-06-30&rft.volume=526&rft.issue=1-2&rft.spage=225&rft.epage=234&rft.pages=225-234&rft.issn=0378-5173&rft.eissn=1873-3476&rft_id=info:doi/10.1016/j.ijpharm.2017.05.004&rft_dat=%3Cproquest_cross%3E1896415997%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1896415997&rft_id=info:pmid/28478278&rft_els_id=S0378517317303964&rfr_iscdi=true |