Oral DNA vaccines based on CS-TPP nanoparticles and alginate microparticles confer high protection against infectious pancreatic necrosis virus (IPNV) infection in trout

Infectious pancreatic necrosis virus (IPNV) is the etiological agent of a contagious viral disease causing remarkable mortalities in different fish species. Despite the availability of commercial vaccines against IPN, the disease still constitutes one of the main threats to the aquaculture industry...

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Veröffentlicht in:	Developmental and comparative immunology 2017-09, Vol.74, p.178-189
Hauptverfasser:	Ahmadivand, Sohrab, Soltani, Mehdi, Behdani, Mahdi, Evensen, Øystein, Alirahimi, Ehsan, Hassanzadeh, Reza, Soltani, Ellahe
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Alginate microparticles Alginates - chemistry Alginic acid Animals Antibodies Antibodies, Viral - blood Aquaculture Birnaviridae Infections - immunology CD4 antigen Chitosan Chitosan - chemistry CS-TPP nanoparticles Deoxyribonucleic acid DNA DNA vaccines Etiology Fish Fish Diseases - immunology Gene expression Gene regulation Genes Glucuronic Acid - chemistry Hexuronic Acids - chemistry Immunity Immunity (Disease) Immunization Immunization, Secondary Immunoglobulin M Immunology Infectious diseases Infectious pancreatic necrosis Infectious pancreatic necrosis virus - physiology Interferon IPNV Kidneys Microparticles Nanoparticles Nanoparticles - chemistry Nanoparticles - therapeutic use Oncorhynchus mykiss Oral administration Oral DNA vaccine Organs Pancreas Polymerase chain reaction Polyphosphates - chemistry Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Transcription Tripolyphosphate Trout Trout - immunology Vaccination Vaccines Vaccines, DNA Viral infections Viral Load Viral Structural Proteins - genetics Viral Vaccines - immunology Viruses
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