Daptomycin: new insights into an antibiotic of last resort

In addition to disrupting the localization of enzymes involved in cell wall biosynthesis, daptomycin also inhibits expression of the alternative Pbp2a, which is required for peptidoglycan biosynthesis by MRSA strains in the presence of β-lactam antibiotics(5). Enhanced approaches to daptomycin thera...

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Veröffentlicht in:	Future microbiology 2017-05, Vol.12 (6), p.461-464
Hauptverfasser:	Pader, Vera, Edwards, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology antibiotic resistance Antibiotics beta-Lactams - pharmacology Biosynthesis Cardiolipin Cell walls Daptomycin Daptomycin - pharmacology Drug resistance Drug Resistance, Bacterial - drug effects Endocarditis Enterococcus faecium - drug effects Fluidity Genotype & phenotype Humans Lipids Localization Membrane fluidity Metabolism Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests MRSA Mutation Osteomyelitis Pathogens Peptidoglycans Phenotypes Phosphatidic acid Purines Pyrimidines Staphylococcus aureus - drug effects Staphylococcus infections Streptococcus - drug effects Supplements Tricarboxylic acid cycle Vancomycin Resistance VRE β-lactam β-Lactam antibiotics
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