Relation of the Number of Parity to Left Ventricular Diastolic Function in Pregnancy
Abstract Left ventricular diastolic dysfunction (LVDD) has been relatively less studied than other cardiac changes during pregnancy. Previous studies revealed a mild diastolic deterioration during pregnancy. However these studies did not evaluate the long-term effect of parity on left ventricular di...
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creator | Keskin, Muhammed, MD Avşar, Şahin, MD Hayıroğlu, Mert İlker, MD Keskin, Taha, MD Börklü, Edibe Betül, MD Kaya, Adnan, MD Uzun, Ahmet Okan, MD Akyol, Burcu, MD Güvenç, Tolga Sinan, MD Kozan, Ömer, MD |
description | Abstract Left ventricular diastolic dysfunction (LVDD) has been relatively less studied than other cardiac changes during pregnancy. Previous studies revealed a mild diastolic deterioration during pregnancy. However these studies did not evaluate the long-term effect of parity on left ventricular diastolic function. A comprehensive study evaluating the long-term effect of parity on diastolic function is required. A total of 710 women with various number of parity were evaluated via echocardiography to reveal the status of diastolic function. Echocardiographic parameters were compared among the women by parity number and categorized accordingly; none, 0< to 4 and 4 < parity (grand multiparous). In nulliparous group, 19 women (23.2 %) had grade 1 LVDD and only 2 women (2.4 %) had grade 2 LVDD. In women with a parity number of 0 < to 4, 209 women (38.3%) had grade 1 LVDD and only 17 women (3.1%) had grade 2 LVDD. In grand multiparous group, only 2 (2.4%) women did not have LVDD and 12 women (14.6 %) had grade 2 LVDD. None of the subjects had grade III or grade IV LVDD. According to hierarchical logistic regression analysis, any grade of LVDD and grade 2 LVDD had the highest rates at parity category of > 4 parity and that had 21 and 5.8-times higher than nulliparous group respectively. In conclusion, according to the current study, grand multiparity but not multiparity, severely deteriorates left ventricular diastolic function. Further studies are warranted to evaluate the risk of gradual diastolic dysfunction after each pregnancy. |
doi_str_mv | 10.1016/j.amjcard.2017.03.244 |
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Previous studies revealed a mild diastolic deterioration during pregnancy. However these studies did not evaluate the long-term effect of parity on left ventricular diastolic function. A comprehensive study evaluating the long-term effect of parity on diastolic function is required. A total of 710 women with various number of parity were evaluated via echocardiography to reveal the status of diastolic function. Echocardiographic parameters were compared among the women by parity number and categorized accordingly; none, 0< to 4 and 4 < parity (grand multiparous). In nulliparous group, 19 women (23.2 %) had grade 1 LVDD and only 2 women (2.4 %) had grade 2 LVDD. In women with a parity number of 0 < to 4, 209 women (38.3%) had grade 1 LVDD and only 17 women (3.1%) had grade 2 LVDD. In grand multiparous group, only 2 (2.4%) women did not have LVDD and 12 women (14.6 %) had grade 2 LVDD. None of the subjects had grade III or grade IV LVDD. According to hierarchical logistic regression analysis, any grade of LVDD and grade 2 LVDD had the highest rates at parity category of > 4 parity and that had 21 and 5.8-times higher than nulliparous group respectively. In conclusion, according to the current study, grand multiparity but not multiparity, severely deteriorates left ventricular diastolic function. Further studies are warranted to evaluate the risk of gradual diastolic dysfunction after each pregnancy.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2017.03.244</identifier><identifier>PMID: 28479168</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Blood pressure ; Cardiovascular ; Diabetes ; Diastole ; Echocardiography ; Female ; Follow-Up Studies ; Heart ; Heart diseases ; Humans ; Middle Aged ; Multivariate analysis ; Parity ; Physiology ; Pregnancy ; Pregnancy Complications, Cardiovascular ; Propagation ; Prospective Studies ; Quality ; Regression analysis ; Risk Factors ; Studies ; Ultrasonic imaging ; Veins & arteries ; Ventricle ; Ventricular Dysfunction, Left - diagnosis ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left - physiology ; Womens health</subject><ispartof>The American journal of cardiology, 2017-07, Vol.120 (1), p.154-159</ispartof><rights>Elsevier Inc.</rights><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Sequoia S.A. Jul 1, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-d9f27de2618102af7f0d9e9ac152e158921c1def42f56bdbc7bff7e5b120764b3</citedby><cites>FETCH-LOGICAL-c514t-d9f27de2618102af7f0d9e9ac152e158921c1def42f56bdbc7bff7e5b120764b3</cites><orcidid>0000-0002-4938-0097</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1907313454?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28479168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keskin, Muhammed, MD</creatorcontrib><creatorcontrib>Avşar, Şahin, MD</creatorcontrib><creatorcontrib>Hayıroğlu, Mert İlker, MD</creatorcontrib><creatorcontrib>Keskin, Taha, MD</creatorcontrib><creatorcontrib>Börklü, Edibe Betül, MD</creatorcontrib><creatorcontrib>Kaya, Adnan, MD</creatorcontrib><creatorcontrib>Uzun, Ahmet Okan, MD</creatorcontrib><creatorcontrib>Akyol, Burcu, MD</creatorcontrib><creatorcontrib>Güvenç, Tolga Sinan, MD</creatorcontrib><creatorcontrib>Kozan, Ömer, MD</creatorcontrib><title>Relation of the Number of Parity to Left Ventricular Diastolic Function in Pregnancy</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Abstract Left ventricular diastolic dysfunction (LVDD) has been relatively less studied than other cardiac changes during pregnancy. Previous studies revealed a mild diastolic deterioration during pregnancy. However these studies did not evaluate the long-term effect of parity on left ventricular diastolic function. A comprehensive study evaluating the long-term effect of parity on diastolic function is required. A total of 710 women with various number of parity were evaluated via echocardiography to reveal the status of diastolic function. Echocardiographic parameters were compared among the women by parity number and categorized accordingly; none, 0< to 4 and 4 < parity (grand multiparous). In nulliparous group, 19 women (23.2 %) had grade 1 LVDD and only 2 women (2.4 %) had grade 2 LVDD. In women with a parity number of 0 < to 4, 209 women (38.3%) had grade 1 LVDD and only 17 women (3.1%) had grade 2 LVDD. In grand multiparous group, only 2 (2.4%) women did not have LVDD and 12 women (14.6 %) had grade 2 LVDD. None of the subjects had grade III or grade IV LVDD. According to hierarchical logistic regression analysis, any grade of LVDD and grade 2 LVDD had the highest rates at parity category of > 4 parity and that had 21 and 5.8-times higher than nulliparous group respectively. In conclusion, according to the current study, grand multiparity but not multiparity, severely deteriorates left ventricular diastolic function. Further studies are warranted to evaluate the risk of gradual diastolic dysfunction after each pregnancy.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood pressure</subject><subject>Cardiovascular</subject><subject>Diabetes</subject><subject>Diastole</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Parity</subject><subject>Physiology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular</subject><subject>Propagation</subject><subject>Prospective Studies</subject><subject>Quality</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Ultrasonic imaging</subject><subject>Veins & arteries</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Left - 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Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keskin, Muhammed, MD</au><au>Avşar, Şahin, MD</au><au>Hayıroğlu, Mert İlker, MD</au><au>Keskin, Taha, MD</au><au>Börklü, Edibe Betül, MD</au><au>Kaya, Adnan, MD</au><au>Uzun, Ahmet Okan, MD</au><au>Akyol, Burcu, MD</au><au>Güvenç, Tolga Sinan, MD</au><au>Kozan, Ömer, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of the Number of Parity to Left Ventricular Diastolic Function in Pregnancy</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>120</volume><issue>1</issue><spage>154</spage><epage>159</epage><pages>154-159</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>Abstract Left ventricular diastolic dysfunction (LVDD) has been relatively less studied than other cardiac changes during pregnancy. Previous studies revealed a mild diastolic deterioration during pregnancy. However these studies did not evaluate the long-term effect of parity on left ventricular diastolic function. A comprehensive study evaluating the long-term effect of parity on diastolic function is required. A total of 710 women with various number of parity were evaluated via echocardiography to reveal the status of diastolic function. Echocardiographic parameters were compared among the women by parity number and categorized accordingly; none, 0< to 4 and 4 < parity (grand multiparous). In nulliparous group, 19 women (23.2 %) had grade 1 LVDD and only 2 women (2.4 %) had grade 2 LVDD. In women with a parity number of 0 < to 4, 209 women (38.3%) had grade 1 LVDD and only 17 women (3.1%) had grade 2 LVDD. In grand multiparous group, only 2 (2.4%) women did not have LVDD and 12 women (14.6 %) had grade 2 LVDD. None of the subjects had grade III or grade IV LVDD. According to hierarchical logistic regression analysis, any grade of LVDD and grade 2 LVDD had the highest rates at parity category of > 4 parity and that had 21 and 5.8-times higher than nulliparous group respectively. In conclusion, according to the current study, grand multiparity but not multiparity, severely deteriorates left ventricular diastolic function. Further studies are warranted to evaluate the risk of gradual diastolic dysfunction after each pregnancy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28479168</pmid><doi>10.1016/j.amjcard.2017.03.244</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4938-0097</orcidid></addata></record> |
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subjects | Adult Aged Blood pressure Cardiovascular Diabetes Diastole Echocardiography Female Follow-Up Studies Heart Heart diseases Humans Middle Aged Multivariate analysis Parity Physiology Pregnancy Pregnancy Complications, Cardiovascular Propagation Prospective Studies Quality Regression analysis Risk Factors Studies Ultrasonic imaging Veins & arteries Ventricle Ventricular Dysfunction, Left - diagnosis Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - physiology Womens health |
title | Relation of the Number of Parity to Left Ventricular Diastolic Function in Pregnancy |
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