Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy

Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy. The molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from dormancy remain uncertain. Here, we use single-cell RNA sequencing (RNA-seq) analysis to show that the transition from dormancy...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2017-05, Vol.169 (5), p.807-823.e19
Hauptverfasser:	Cabezas-Wallscheid, Nina, Buettner, Florian, Sommerkamp, Pia, Klimmeck, Daniel, Ladel, Luisa, Thalheimer, Frederic B., Pastor-Flores, Daniel, Roma, Leticia P., Renders, Simon, Zeisberger, Petra, Przybylla, Adriana, Schönberger, Katharina, Scognamiglio, Roberta, Altamura, Sandro, Florian, Carolina M., Fawaz, Malak, Vonficht, Dominik, Tesio, Melania, Collier, Paul, Pavlinic, Dinko, Geiger, Hartmut, Schroeder, Timm, Benes, Vladimir, Dick, Tobias P., Rieger, Michael A., Stegle, Oliver, Trumpp, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATRA Biosynthetic Pathways Cell Culture Techniques Cell Cycle - drug effects Cell Survival Diet dormancy Gene Expression Profiling hematopoietic stem cell Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects HSC Mice Poly I-C - pharmacology Reactive Oxygen Species - metabolism Receptors, G-Protein-Coupled - metabolism reporter retinoic acid RNA-seq Signal Transduction single-cell Single-Cell Analysis Stress, Physiological Tretinoin - pharmacology vitamin A Vitamin A - administration & dosage Vitamin A - pharmacology Vitamins - administration & dosage Vitamins - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!