The Scaffolding Protein RACK1 Interacts with Androgen Receptor and Promotes Cross-talk through a Protein Kinase C Signaling Pathway

The androgen receptor (AR), a member of the nuclear hormone receptor superfamily, functions as a ligand-dependent transcription factor that regulates genes involved in cell proliferation and differentiation. Using a C-terminal region of the human AR in a yeast two-hybrid screen, we have identified R...

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Veröffentlicht in:	The Journal of biological chemistry 2003-11, Vol.278 (46), p.46087-46093
Hauptverfasser:	Rigas, Anastasia C., Ozanne, Daniel M., Neal, David E., Robson, Craig N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals beta-Galactosidase - metabolism Blotting, Western Cell Differentiation Cell Division Cell Line, Tumor Chromatin - metabolism COS Cells Gene Deletion Humans Indoles - pharmacology Lactams - pharmacology Ligands Microscopy, Fluorescence Peptides - chemistry Peptides - metabolism Precipitin Tests Protein Binding Protein Isoforms Protein Kinase C - metabolism Protein Structure, Tertiary RACK1 protein Receptors for Activated C Kinase Receptors, Androgen - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Time Factors Transcription, Genetic Transcriptional Activation Two-Hybrid System Techniques
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