Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects

Several studies have shown a relationship between interleukin (IL) 6 levels and insulin resistance. We here show that human subcutaneous adipose cells, like 3T3-L1 cells, are target cells for IL-6. To examine putative mechanisms and cross-talk with insulin, 3T3-L1 adipocytes were cultured for differ...

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Veröffentlicht in:	The Journal of biological chemistry 2003-11, Vol.278 (46), p.45777-45784
Hauptverfasser:	Rotter, Victoria, Nagaev, Ivan, Smith, Ulf
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - metabolism Adipose Tissue - metabolism Adult Animals Biological Transport Blotting, Northern Cytokines - metabolism Dose-Response Relationship, Drug Glucose - metabolism glucose transporter GLUT4 Glucose Transporter Type 4 GLUT-4 protein Humans Insulin Receptor Substrate Proteins insulin receptors Insulin Resistance insulin-receptor substrate 1 protein insulin-receptor substrate 2 Interleukin-6 - metabolism Interleukin-8 - metabolism IRS-1 protein JNK Mitogen-Activated Protein Kinases JNK protein MAP Kinase Kinase 4 Mice Middle Aged Mitogen-Activated Protein Kinase Kinases - metabolism Monosaccharide Transport Proteins - metabolism Muscle Proteins peroxisome proliferator-activated receptors Phosphoproteins - metabolism Phosphorylation Proteins - metabolism pS-307 protein Repressor Proteins Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism RNA, Messenger - metabolism Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Time Factors Transcription Factors Transcription, Genetic Tumor Necrosis Factor-alpha - metabolism Tyrosine - chemistry Tyrosine - metabolism Up-Regulation
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