Regulation of Vascular Smooth Muscle Cell Responses to Insulin-like Growth Factor (IGF)-I by Local IGF-binding Proteins

Insulin-like growth factor (IGF)-I is a pleiotropic hormone that regulates vascular smooth muscle cell (VSMC) migration, proliferation, apoptosis, and differentiation. These actions are mediated by the IGF-I receptor. How activation of the same receptor by the same ligand leads to these diverse cell...

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Veröffentlicht in:	The Journal of biological chemistry 2003-10, Vol.278 (44), p.42886-42892
Hauptverfasser:	Hsieh, Tzefu, Gordon, Rebecca E., Clemmons, David R., Busby, Walker H., Duan, Cunming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - metabolism Cell Movement Chemotaxis DNA - metabolism Dose-Response Relationship, Drug Glycosaminoglycans - metabolism Heparan Sulfate Proteoglycans - metabolism Heparin Lyase - metabolism IGFBP-5 protein Insulin-Like Growth Factor Binding Protein 2 - metabolism Insulin-Like Growth Factor Binding Protein 4 - metabolism Insulin-Like Growth Factor Binding Protein 5 - metabolism Insulin-Like Growth Factor I - metabolism Ligands Muscle, Smooth, Vascular - cytology Mutation Protein Binding Swine - metabolism Time Factors Transfection
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