Association Between Polymorphisms in the Purinergic P2Y12 Receptor Gene and Severity of Both Cancer Pain and Postoperative Pain

Abstract Background Despite the widespread use of opioids for the treatment of cancer pain, results from several surveys consistently show that pain is still prevalent in some patients with malignant diseases. The purinergic P2Y12 receptor is a primary site leading to microglial activation and hyper...

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Veröffentlicht in:	Pain medicine (Malden, Mass.) Mass.), 2018-02, Vol.19 (2), p.348-354
Hauptverfasser:	Sumitani, Masahiko, Nishizawa, Daisuke, Nagashima, Makoto, Ikeda, Kazutaka, Abe, Hiroaki, Kato, Ryoji, Ueda, Hiroshi, Yamada, Yoshitsugu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Cancer Cancer genetics Cancer pain Cancer Pain - genetics Cancer treatment Care and treatment Chromosomes Comparative analysis Female Genes Genetic polymorphisms Genetic variability Genotype Genotypes Genotyping Humans Linkage disequilibrium Male Middle Aged Narcotics Neuronal-glial interactions Neurons Opioids Pain Pain management Pain perception Pain, Postoperative - genetics Patients Polymorphism, Single Nucleotide Postoperative pain Postoperative period Receptors, Purinergic P2Y12 - genetics Single nucleotide polymorphisms Single-nucleotide polymorphism Surveys
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