A fiducial skull marker for precise MRI-based stereotaxic surgery in large animal models

•Precise coordinates are needed for delicate stereotaxic procedures.•Fiducial markers can easily be made in any laboratory.•Using MRI visible fiducial markers inserted in the skull allow high precision targeting of cortical and subcortical targets. Stereotaxic neurosurgery in large animals is used w...

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Veröffentlicht in:Journal of neuroscience methods 2017-06, Vol.285, p.45-48
Hauptverfasser: Glud, Andreas Nørgaard, Bech, Johannes, Tvilling, Laura, Zaer, Hamed, Orlowski, Dariusz, Fitting, Lise Moberg, Ziedler, Dora, Geneser, Michael, Sangill, Ryan, Alstrup, Aage Kristian Olsen, Bjarkam, Carsten Reidies, Sørensen, Jens Christian Hedemann
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container_issue
container_start_page 45
container_title Journal of neuroscience methods
container_volume 285
creator Glud, Andreas Nørgaard
Bech, Johannes
Tvilling, Laura
Zaer, Hamed
Orlowski, Dariusz
Fitting, Lise Moberg
Ziedler, Dora
Geneser, Michael
Sangill, Ryan
Alstrup, Aage Kristian Olsen
Bjarkam, Carsten Reidies
Sørensen, Jens Christian Hedemann
description •Precise coordinates are needed for delicate stereotaxic procedures.•Fiducial markers can easily be made in any laboratory.•Using MRI visible fiducial markers inserted in the skull allow high precision targeting of cortical and subcortical targets. Stereotaxic neurosurgery in large animals is used widely in different sophisticated models, where precision is becoming more crucial as desired anatomical target regions are becoming smaller. Individually calculated coordinates are necessary in large animal models with cortical and subcortical anatomical differences. We present a convenient method to make an MRI-visible skull fiducial for 3D MRI-based stereotaxic procedures in larger experimental animals. Plastic screws were filled with either copper-sulfate solution or MRI-visible paste from a commercially available cranial head marker. The screw fiducials were inserted in the animal skulls and T1 weighted MRI was performed allowing identification of the inserted skull marker. Both types of fiducial markers were clearly visible on the MRÍs. This allows high precision in the stereotaxic space. The use of skull bone based fiducial markers gives high precision for both targeting and evaluation of stereotaxic systems. There are no metal artifacts and the fiducial is easily removed after surgery. The fiducial marker can be used as a very precise reference point, either for direct targeting or in evaluation of other stereotaxic systems.
doi_str_mv 10.1016/j.jneumeth.2017.04.017
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Stereotaxic neurosurgery in large animals is used widely in different sophisticated models, where precision is becoming more crucial as desired anatomical target regions are becoming smaller. Individually calculated coordinates are necessary in large animal models with cortical and subcortical anatomical differences. We present a convenient method to make an MRI-visible skull fiducial for 3D MRI-based stereotaxic procedures in larger experimental animals. Plastic screws were filled with either copper-sulfate solution or MRI-visible paste from a commercially available cranial head marker. The screw fiducials were inserted in the animal skulls and T1 weighted MRI was performed allowing identification of the inserted skull marker. Both types of fiducial markers were clearly visible on the MRÍs. This allows high precision in the stereotaxic space. The use of skull bone based fiducial markers gives high precision for both targeting and evaluation of stereotaxic systems. 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source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Animals
Copper Sulfate - therapeutic use
Fiducial Markers - standards
Functional neurosurgery
Göttingen minipig
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Models, Animal
MRI-compatible surgery
Pig
Skull - diagnostic imaging
Skull - surgery
Stereotaxic surgery
Stereotaxic Techniques
Swine - surgery
title A fiducial skull marker for precise MRI-based stereotaxic surgery in large animal models
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