$Brigatinib in Patients With Crizotinib-Refractory Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer: A Randomized, Multicenter Phase II Trial$

Brigatinib in Patients With Crizotinib-Refractory Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer: A Randomized, Multicenter Phase II Trial

Purpose Most crizotinib-treated patients with anaplastic lymphoma kinase gene ( ALK)-rearranged non-small-cell lung cancer (ALK-positive NSCLC) eventually experience disease progression. We evaluated two regimens of brigatinib, an investigational next-generation ALK inhibitor, in crizotinib-refracto...

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Veröffentlicht in:	Journal of clinical oncology 2017-08, Vol.35 (22), p.2490-2498
Hauptverfasser:	Kim, Dong-Wan, Tiseo, Marcello, Ahn, Myung-Ju, Reckamp, Karen L, Hansen, Karin Holmskov, Kim, Sang-We, Huber, Rudolf M, West, Howard L, Groen, Harry J M, Hochmair, Maximilian J, Leighl, Natasha B, Gettinger, Scott N, Langer, Corey J, Paz-Ares Rodríguez, Luis G, Smit, Egbert F, Kim, Edward S, Reichmann, William, Haluska, Frank G, Kerstein, David, Camidge, D Ross
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Anaplastic Lymphoma Kinase Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Brain Neoplasms - drug therapy Brain Neoplasms - secondary Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - secondary Cough - chemically induced Crizotinib Diarrhea - chemically induced Disease Progression Disease-Free Survival Female Headache - chemically induced Humans Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male Middle Aged Nausea - chemically induced Organophosphorus Compounds - administration & dosage Organophosphorus Compounds - adverse effects Organophosphorus Compounds - therapeutic use Prospective Studies Pyrazoles - therapeutic use Pyridines - therapeutic use Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrimidines - therapeutic use Receptor Protein-Tyrosine Kinases - genetics Retreatment Treatment Outcome Young Adult
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