Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival

A decline in proteasome function is causally connected to neuronal aging and aging-associated neuropathologies. By using hippocampal neurons in culture and in vivo, we show that aging triggers a reduction and a cytoplasm-to-nucleus redistribution of the E3 ubiquitin ligase mahogunin (MGRN1). Proteas...

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Veröffentlicht in:	Molecular cell 2017-05, Vol.66 (3), p.358-372.e7
Hauptverfasser:	Benvegnù, Stefano, Mateo, María Inés, Palomer, Ernest, Jurado-Arjona, Jerónimo, Dotti, Carlos G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - genetics Activating Transcription Factor 3 - metabolism Active Transport, Cell Nucleus aging Aging - genetics Aging - metabolism Aging - pathology Animals ATF3 Behavior, Animal Cell Nucleus - enzymology Cell Nucleus - ultrastructure Cell Survival Chromatin - enzymology Cognition Cytoplasm - enzymology HEK293 Cells hippocampus Hippocampus - enzymology Hippocampus - ultrastructure Humans mahogunin Maze Learning Mice, Inbred C57BL neuron Neurons - enzymology Neurons - ultrastructure proteasome Proteasome Endopeptidase Complex - metabolism Rats, Wistar RNA Interference Signal Transduction stress response Stress, Physiological survival Transcription, Genetic Transfection ubiquitin Ubiquitin - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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