Epigenome-wide association study of rheumatoid arthritis identifies differentially methylated loci in B cells

Epigenetic regulation of immune cell types could be critical for the development and maintenance of autoimmune diseases like rheumatoid arthritis (RA). B cells are highly relevant in RA, since patients express autoantibodies and depleting this cell type is a successful therapeutic approach. Epigenet...

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Veröffentlicht in:	Human molecular genetics 2017-07, Vol.26 (14), p.2803-2811
Hauptverfasser:	Julià, Antonio, Absher, Devin, López-Lasanta, María, Palau, Nuria, Pluma, Andrea, Waite Jones, Lindsay, Glossop, John R, Farrell, William E, Myers, Richard M, Marsal, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism B-Lymphocytes - metabolism Case-Control Studies Cohort Studies CpG Islands - genetics DNA Methylation - genetics Epigenesis, Genetic - genetics Epigenomics - methods Female Genome-Wide Association Study - methods Humans Lupus Erythematosus, Systemic - genetics Male Middle Aged Signal Transduction
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