Upregulated expression of Nucleostemin/GNL3 is associated with poor prognosis and Sorafenib Resistance in Hepatocellular Carcinoma

Nucleostemin (NS)/GNL3 protein has been recently documented to be a nucleolar protein that was abundantly expressed in stem cells and cancer cells. Herein, we showed that NS was upregulated in HCC tissues and the expression of NS was inversely correlated with that of p53. Overexpression of NS predic...

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Veröffentlicht in:	Pathology, research and practice research and practice, 2017-06, Vol.213 (6), p.688-697
Hauptverfasser:	Hua, Lu, Hu, Baoying, Yan, Daliang, Liu, Jinxia, Shen, Yifen, Zhao, Fengbo, Shen, Chaoyan, Chen, Buyou, Cui, Xiaopeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell Line, Tumor Drug Resistance, Neoplasm - physiology Female GTP-Binding Proteins - metabolism Hepatocellular carcinoma Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - mortality Liver Neoplasms - pathology Male Middle Aged Niacinamide - analogs & derivatives Niacinamide - pharmacology Niacinamide - therapeutic use Nuclear Proteins - metabolism Nucleostemin/GNL3 p53 Phenylurea Compounds - pharmacology Phenylurea Compounds - therapeutic use Prognosis Proto-Oncogene Proteins c-bcl-2 - metabolism Sorafenib resistance Survival Rate Up-Regulation Young Adult
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