Cytokine Biomarkers of Disease Activity and Therapeutic Response after Initiating Methotrexate Therapy in Patients with Juvenile Idiopathic Arthritis

Study Objective To evaluate the relationship between plasma cytokine levels with disease activity and therapeutic response in patients with juvenile idiopathic arthritis (JIA) after initiating methotrexate (MTX) therapy. Design Single‐center observational prospective cohort study. Setting Outpatient...

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Veröffentlicht in:	Pharmacotherapy 2017-06, Vol.37 (6), p.700-711
Hauptverfasser:	Funk, Ryan S., Chan, Marcia A., Becker, Mara L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antirheumatic Agents - therapeutic use Arthritis Arthritis, Juvenile - blood Arthritis, Juvenile - diagnosis Arthritis, Juvenile - drug therapy Bioindicators biomarkers Biomarkers - blood Child Child, Preschool Cohort Studies Cytokines Cytokines - blood Disease Progression Etanercept Female Health risk assessment Humans Infant Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 receptors Interleukin 6 juvenile idiopathic arthritis Male Medical personnel Methotrexate Methotrexate - therapeutic use Pediatrics Pharmacodynamics Prospective Studies Treatment Outcome Tumor necrosis factor Tumor necrosis factor-TNF
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