Recombinant factor VIIa addition to haemophilic blood perfused over collagen/tissue factor can sufficiently bypass the factor IXa/VIIIa defect to rescue fibrin generation

Introduction Factor VIII (FVIII) or factor IX (FIX)‐deficient haemophilic patients display deficits in platelet and fibrin deposition under flow detectable in microfluidics. Compared to fibrin generation, decreased platelet deposition in haemophilic blood flow is more easily rescued with recombinant...

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Veröffentlicht in:	Haemophilia : the official journal of the World Federation of Hemophilia 2017-09, Vol.23 (5), p.759-768
Hauptverfasser:	Li, R., Panckeri, K. A., Fogarty, P. F., Cuker, A., Diamond, S. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Coagulation - drug effects Blood Coagulation Tests Blood flow Blood platelets Blood Platelets - metabolism Coagulation factor VIIa Coagulation factors Collagen Collagen - administration & dosage Collagen - metabolism Factor VIIa - administration & dosage Factor VIII deficiency Fibrin Fibrin - biosynthesis haemophilia Hemophilia Hemophilia A - blood Hemophilia A - diagnosis Hemophilia A - drug therapy Hemophilia B - blood Hemophilia B - diagnosis Hemophilia B - drug therapy Humans Microfluidics Models, Biological Perfusion Platelet Activation - drug effects Platelet Adhesiveness - drug effects Platelets Protein Binding recombinant FVIIa Recombinant Proteins - administration & dosage Signal Transduction Thrombin Thromboplastin - administration & dosage Thromboplastin - metabolism Tissue factor Trypsin
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