Excessive Iodine Intake and Thyrotropin Reference Interval: Data from the Korean National Health and Nutrition Examination Survey
Background: Iodine intake is associated with various thyroid diseases and serum thyrotropin (TSH) levels. The aim of this study was to investigate iodine intake and its impact on the distribution of serum TSH levels using nationwide data from Korea, a country known to be iodine replete. Methods: The...
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| Veröffentlicht in: | Thyroid (New York, N.Y.) N.Y.), 2017-07, Vol.27 (7), p.967-972 |
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| creator | Jeon, Min Ji Kim, Won Gu Kwon, Hyemi Kim, Mijin Park, Suyeon Oh, Hye-Seon Han, Minkyu Kim, Tae Yong Shong, Young Kee Kim, Won Bae |
| description | Background:
Iodine intake is associated with various thyroid diseases and serum thyrotropin (TSH) levels. The aim of this study was to investigate iodine intake and its impact on the distribution of serum TSH levels using nationwide data from Korea, a country known to be iodine replete.
Methods:
The sixth Korean National Health and Nutrition Examination Survey (2013–2015) is a nationwide, cross-sectional survey of the Korean general population. Participants were selected using two-stage stratified cluster sampling of the population and housing census data. A total of 6564 participants aged ≥10 years who underwent thyroid function tests and urinary iodine level measurements during the survey were included in this study.
Results:
The median urinary iodine concentration (UIC) was 299.3 μg/L (interquartile range 158.8–699.8), suggesting more than adequate iodine intake in Korea. With high-iodine intake in all age groups and in both females and males, the TSH reference interval in the Korean reference population was right-shifted at 0.62–6.84 mIU/L. The prevalence of overt and subclinical hypothyroidism in Korea according to this reference interval was 0.73% and 3.12%, respectively, and was significantly associated with nutritional iodine status (
p
= 0.011 and
p
|
| doi_str_mv | 10.1089/thy.2017.0078 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1895277207</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1895277207</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-4a6c4291f3f5e3b2af18105a5969249a4185d3c6d304aa61fe02fc501d0c918f3</originalsourceid><addsrcrecordid>eNqFkEFP3DAQha2KqlDokWvlI5dsbSeO494QbAsqolKh52jWGWtNE3uxnRV77D9vskt77emNnj49aT5CzjlbcNboT3m9WwjG1YIx1bwhJ1xKVWim1NF0M8kKJWR9TN6n9MQYrxtVviPHoqkUF7o6Ib-XLwZTclukt6Fzfgqf4RdS8B19XO9iyDFsnKc_0GJEb_YAxi30n-k1ZKA2hoHmNdJvISJ4eg_ZBQ89vUHo83o_dD_m6OaaLl9gcH6P0IcxbnF3Rt5a6BN-eM1T8vPL8vHqprj7_vX26vKuMBUrc1FBbSqhuS2txHIlwPJm-g-krrWoNFS8kV1p6q5kFUDNLTJhjWS8Y0bzxpan5OKwu4nhecSU28Elg30PHsOYWt5oKZQSTE1ocUBNDClFtO0mugHiruWsna23k_V2tt7O1if-4-v0uBqw-0f_1TwB5QGYa_C-d7jCmP8z-webY5BH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1895277207</pqid></control><display><type>article</type><title>Excessive Iodine Intake and Thyrotropin Reference Interval: Data from the Korean National Health and Nutrition Examination Survey</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Jeon, Min Ji ; Kim, Won Gu ; Kwon, Hyemi ; Kim, Mijin ; Park, Suyeon ; Oh, Hye-Seon ; Han, Minkyu ; Kim, Tae Yong ; Shong, Young Kee ; Kim, Won Bae</creator><creatorcontrib>Jeon, Min Ji ; Kim, Won Gu ; Kwon, Hyemi ; Kim, Mijin ; Park, Suyeon ; Oh, Hye-Seon ; Han, Minkyu ; Kim, Tae Yong ; Shong, Young Kee ; Kim, Won Bae</creatorcontrib><description>Background:
Iodine intake is associated with various thyroid diseases and serum thyrotropin (TSH) levels. The aim of this study was to investigate iodine intake and its impact on the distribution of serum TSH levels using nationwide data from Korea, a country known to be iodine replete.
Methods:
The sixth Korean National Health and Nutrition Examination Survey (2013–2015) is a nationwide, cross-sectional survey of the Korean general population. Participants were selected using two-stage stratified cluster sampling of the population and housing census data. A total of 6564 participants aged ≥10 years who underwent thyroid function tests and urinary iodine level measurements during the survey were included in this study.
Results:
The median urinary iodine concentration (UIC) was 299.3 μg/L (interquartile range 158.8–699.8), suggesting more than adequate iodine intake in Korea. With high-iodine intake in all age groups and in both females and males, the TSH reference interval in the Korean reference population was right-shifted at 0.62–6.84 mIU/L. The prevalence of overt and subclinical hypothyroidism in Korea according to this reference interval was 0.73% and 3.12%, respectively, and was significantly associated with nutritional iodine status (
p
= 0.011 and
p
< 0.001, respectively).
Conclusions:
This first nationwide survey demonstrates more than adequate iodine intake and a right-shifted distribution of serum TSH levels in the Korean general population. Nutritional iodine status is important for determining serum TSH levels and is associated with a high prevalence of hypothyroidism. Nutritional iodine status might need to be considered when establishing TSH reference intervals of populations in iodine-replete areas.</description><identifier>ISSN: 1050-7256</identifier><identifier>EISSN: 1557-9077</identifier><identifier>DOI: 10.1089/thy.2017.0078</identifier><identifier>PMID: 28471294</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adult ; Cross-Sectional Studies ; Diet ; Female ; Health Surveys ; Humans ; Iodine - urine ; Iodine and Endemic Goiter ; Male ; Middle Aged ; Nutritional Status ; Reference Values ; Republic of Korea ; Thyroid Function Tests ; Thyrotropin - blood ; Thyroxine - blood ; Young Adult</subject><ispartof>Thyroid (New York, N.Y.), 2017-07, Vol.27 (7), p.967-972</ispartof><rights>2017, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-4a6c4291f3f5e3b2af18105a5969249a4185d3c6d304aa61fe02fc501d0c918f3</citedby><cites>FETCH-LOGICAL-c403t-4a6c4291f3f5e3b2af18105a5969249a4185d3c6d304aa61fe02fc501d0c918f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28471294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeon, Min Ji</creatorcontrib><creatorcontrib>Kim, Won Gu</creatorcontrib><creatorcontrib>Kwon, Hyemi</creatorcontrib><creatorcontrib>Kim, Mijin</creatorcontrib><creatorcontrib>Park, Suyeon</creatorcontrib><creatorcontrib>Oh, Hye-Seon</creatorcontrib><creatorcontrib>Han, Minkyu</creatorcontrib><creatorcontrib>Kim, Tae Yong</creatorcontrib><creatorcontrib>Shong, Young Kee</creatorcontrib><creatorcontrib>Kim, Won Bae</creatorcontrib><title>Excessive Iodine Intake and Thyrotropin Reference Interval: Data from the Korean National Health and Nutrition Examination Survey</title><title>Thyroid (New York, N.Y.)</title><addtitle>Thyroid</addtitle><description>Background:
Iodine intake is associated with various thyroid diseases and serum thyrotropin (TSH) levels. The aim of this study was to investigate iodine intake and its impact on the distribution of serum TSH levels using nationwide data from Korea, a country known to be iodine replete.
Methods:
The sixth Korean National Health and Nutrition Examination Survey (2013–2015) is a nationwide, cross-sectional survey of the Korean general population. Participants were selected using two-stage stratified cluster sampling of the population and housing census data. A total of 6564 participants aged ≥10 years who underwent thyroid function tests and urinary iodine level measurements during the survey were included in this study.
Results:
The median urinary iodine concentration (UIC) was 299.3 μg/L (interquartile range 158.8–699.8), suggesting more than adequate iodine intake in Korea. With high-iodine intake in all age groups and in both females and males, the TSH reference interval in the Korean reference population was right-shifted at 0.62–6.84 mIU/L. The prevalence of overt and subclinical hypothyroidism in Korea according to this reference interval was 0.73% and 3.12%, respectively, and was significantly associated with nutritional iodine status (
p
= 0.011 and
p
< 0.001, respectively).
Conclusions:
This first nationwide survey demonstrates more than adequate iodine intake and a right-shifted distribution of serum TSH levels in the Korean general population. Nutritional iodine status is important for determining serum TSH levels and is associated with a high prevalence of hypothyroidism. Nutritional iodine status might need to be considered when establishing TSH reference intervals of populations in iodine-replete areas.</description><subject>Adult</subject><subject>Cross-Sectional Studies</subject><subject>Diet</subject><subject>Female</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Iodine - urine</subject><subject>Iodine and Endemic Goiter</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nutritional Status</subject><subject>Reference Values</subject><subject>Republic of Korea</subject><subject>Thyroid Function Tests</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Young Adult</subject><issn>1050-7256</issn><issn>1557-9077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFP3DAQha2KqlDokWvlI5dsbSeO494QbAsqolKh52jWGWtNE3uxnRV77D9vskt77emNnj49aT5CzjlbcNboT3m9WwjG1YIx1bwhJ1xKVWim1NF0M8kKJWR9TN6n9MQYrxtVviPHoqkUF7o6Ib-XLwZTclukt6Fzfgqf4RdS8B19XO9iyDFsnKc_0GJEb_YAxi30n-k1ZKA2hoHmNdJvISJ4eg_ZBQ89vUHo83o_dD_m6OaaLl9gcH6P0IcxbnF3Rt5a6BN-eM1T8vPL8vHqprj7_vX26vKuMBUrc1FBbSqhuS2txHIlwPJm-g-krrWoNFS8kV1p6q5kFUDNLTJhjWS8Y0bzxpan5OKwu4nhecSU28Elg30PHsOYWt5oKZQSTE1ocUBNDClFtO0mugHiruWsna23k_V2tt7O1if-4-v0uBqw-0f_1TwB5QGYa_C-d7jCmP8z-webY5BH</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Jeon, Min Ji</creator><creator>Kim, Won Gu</creator><creator>Kwon, Hyemi</creator><creator>Kim, Mijin</creator><creator>Park, Suyeon</creator><creator>Oh, Hye-Seon</creator><creator>Han, Minkyu</creator><creator>Kim, Tae Yong</creator><creator>Shong, Young Kee</creator><creator>Kim, Won Bae</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170701</creationdate><title>Excessive Iodine Intake and Thyrotropin Reference Interval: Data from the Korean National Health and Nutrition Examination Survey</title><author>Jeon, Min Ji ; Kim, Won Gu ; Kwon, Hyemi ; Kim, Mijin ; Park, Suyeon ; Oh, Hye-Seon ; Han, Minkyu ; Kim, Tae Yong ; Shong, Young Kee ; Kim, Won Bae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-4a6c4291f3f5e3b2af18105a5969249a4185d3c6d304aa61fe02fc501d0c918f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Cross-Sectional Studies</topic><topic>Diet</topic><topic>Female</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Iodine - urine</topic><topic>Iodine and Endemic Goiter</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nutritional Status</topic><topic>Reference Values</topic><topic>Republic of Korea</topic><topic>Thyroid Function Tests</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeon, Min Ji</creatorcontrib><creatorcontrib>Kim, Won Gu</creatorcontrib><creatorcontrib>Kwon, Hyemi</creatorcontrib><creatorcontrib>Kim, Mijin</creatorcontrib><creatorcontrib>Park, Suyeon</creatorcontrib><creatorcontrib>Oh, Hye-Seon</creatorcontrib><creatorcontrib>Han, Minkyu</creatorcontrib><creatorcontrib>Kim, Tae Yong</creatorcontrib><creatorcontrib>Shong, Young Kee</creatorcontrib><creatorcontrib>Kim, Won Bae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thyroid (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeon, Min Ji</au><au>Kim, Won Gu</au><au>Kwon, Hyemi</au><au>Kim, Mijin</au><au>Park, Suyeon</au><au>Oh, Hye-Seon</au><au>Han, Minkyu</au><au>Kim, Tae Yong</au><au>Shong, Young Kee</au><au>Kim, Won Bae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excessive Iodine Intake and Thyrotropin Reference Interval: Data from the Korean National Health and Nutrition Examination Survey</atitle><jtitle>Thyroid (New York, N.Y.)</jtitle><addtitle>Thyroid</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>27</volume><issue>7</issue><spage>967</spage><epage>972</epage><pages>967-972</pages><issn>1050-7256</issn><eissn>1557-9077</eissn><abstract>Background:
Iodine intake is associated with various thyroid diseases and serum thyrotropin (TSH) levels. The aim of this study was to investigate iodine intake and its impact on the distribution of serum TSH levels using nationwide data from Korea, a country known to be iodine replete.
Methods:
The sixth Korean National Health and Nutrition Examination Survey (2013–2015) is a nationwide, cross-sectional survey of the Korean general population. Participants were selected using two-stage stratified cluster sampling of the population and housing census data. A total of 6564 participants aged ≥10 years who underwent thyroid function tests and urinary iodine level measurements during the survey were included in this study.
Results:
The median urinary iodine concentration (UIC) was 299.3 μg/L (interquartile range 158.8–699.8), suggesting more than adequate iodine intake in Korea. With high-iodine intake in all age groups and in both females and males, the TSH reference interval in the Korean reference population was right-shifted at 0.62–6.84 mIU/L. The prevalence of overt and subclinical hypothyroidism in Korea according to this reference interval was 0.73% and 3.12%, respectively, and was significantly associated with nutritional iodine status (
p
= 0.011 and
p
< 0.001, respectively).
Conclusions:
This first nationwide survey demonstrates more than adequate iodine intake and a right-shifted distribution of serum TSH levels in the Korean general population. Nutritional iodine status is important for determining serum TSH levels and is associated with a high prevalence of hypothyroidism. Nutritional iodine status might need to be considered when establishing TSH reference intervals of populations in iodine-replete areas.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>28471294</pmid><doi>10.1089/thy.2017.0078</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Cross-Sectional Studies Diet Female Health Surveys Humans Iodine - urine Iodine and Endemic Goiter Male Middle Aged Nutritional Status Reference Values Republic of Korea Thyroid Function Tests Thyrotropin - blood Thyroxine - blood Young Adult |
| title | Excessive Iodine Intake and Thyrotropin Reference Interval: Data from the Korean National Health and Nutrition Examination Survey |
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