Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency

Naive pluripotent stem cells (PSCs) utilize both glycolysis and oxidative phosphorylation (OXPHOS) to satisfy their metabolic demands. However, it is unclear how somatic cells acquire this hybrid energy metabolism during reprogramming toward naive pluripotency. Here, we show that when transduced wit...

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Veröffentlicht in:	Cell metabolism 2017-05, Vol.25 (5), p.1103-1117.e6
Hauptverfasser:	Sone, Masamitsu, Morone, Nobuhiro, Nakamura, Tomonori, Tanaka, Akito, Okita, Keisuke, Woltjen, Knut, Nakagawa, Masato, Heuser, John E., Yamada, Yasuhiro, Yamanaka, Shinya, Yamamoto, Takuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cells, Cultured Cellular Reprogramming epistem cell Esrrb Fibroblasts - cytology Fibroblasts - metabolism Glycolysis Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans hypoxia inducible factor Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Mice, Inbred C57BL Mice, Inbred ICR Mitochondria Oxidative Phosphorylation Pgc1a Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Transcription Factors - genetics Transcription Factors - metabolism Up-Regulation Zic3
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