Accurate p‐values for adaptive designs with binary endpoints

Adaptive designs encompass all trials allowing various types of design modifications over the course of the trial. A key requirement for confirmatory adaptive designs to be accepted by regulators is the strong control of the family‐wise error rate. This can be achieved by combining the p‐values for...

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Veröffentlicht in:	Statistics in medicine 2017-07, Vol.36 (17), p.2643-2655
Hauptverfasser:	Heritier, Stephane, Lloyd, Chris J., Lô, Serigne N.
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptive design Bias bootstrap p‐value Clinical trials Clinical Trials as Topic - methods combination test Computer Simulation Data Interpretation, Statistical familywise error rate Humans Likelihood Functions Medical statistics Reproducibility of Results Research Design Sample Size second‐order test Simes
Online-Zugang:	Volltext
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