Changes in the brain κ-opioid receptor levels of rats in withdrawal from physical dependence upon butorphanol

Changes in κ-opioid receptor levels have been implicated in the development of physical dependence upon and withdrawal from the mixed agonist–antagonist opioid, butorphanol. Immunoblotting analysis was performed to determine the levels of κ- and μ-opioid receptors in brain regions of rats in withdra...

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Veröffentlicht in:	Neuroscience 2003-01, Vol.121 (4), p.1063-1074
Hauptverfasser:	Fan, L.-W, Tien, L.-T, Tanaka, S, Ma, T, Chudapongse, N, Sinchaisuk, S, Rockhold, R.W, Ho, I.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Behavior, Animal - drug effects Biological and medical sciences Brain - drug effects Brain - metabolism butorphanol Butorphanol - adverse effects immunoblotting analysis Male Medical sciences morphine Morphine - adverse effects Naloxone - pharmacology Narcotic Antagonists - pharmacology Narcotics - adverse effects Neuropharmacology Opioid-Related Disorders - metabolism Opioid-Related Disorders - physiopathology Pharmacology. Drug treatments physical dependence Rats Rats, Sprague-Dawley Receptors, Opioid, kappa - drug effects Receptors, Opioid, kappa - metabolism Receptors, Opioid, mu - drug effects Receptors, Opioid, mu - metabolism Substance Withdrawal Syndrome - metabolism Substance Withdrawal Syndrome - physiopathology Up-Regulation - drug effects Up-Regulation - physiology withdrawal κ-opioid receptors
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