Conformational latitude – activity relationship of KPPR tetrapeptide analogues toward their ability to inhibit binding of vascular endothelial growth factor 165 to neuropilin‐1

Neuropilin‐1 (NRP‐1) has been found to be overexpressed in several kinds of malignant tumors, and it is postulated that in pathological angiogenesis, its interaction with the vascular endothelial growth factor 165 (VEGF165) leads to progression of tumor vascularization and growth. Herein, we present...

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Veröffentlicht in:	Journal of peptide science 2017-06, Vol.23 (6), p.445-454
Hauptverfasser:	Fedorczyk, Bartlomiej, Lipiński, Piotr F. J., Tymecka, Dagmara, Puszko, Anna K., Wilenska, Beata, Perret, Gerard Y., Misicka, Aleksandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino acids Angiogenesis Binding Sites - drug effects Chemical synthesis conformational latitude Dose-Response Relationship, Drug Growth factors Humans Inhibitors inhibitors of NRP‐1 Models, Molecular Molecular dynamics Neuropilin Neuropilin-1 - antagonists & inhibitors Neuropilin-1 - chemistry Oligopeptides - chemical synthesis Oligopeptides - chemistry Oligopeptides - pharmacology Peptides Peptidomimetics Protein Conformation Residues Structure-Activity Relationship Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - chemistry Vascularization VEGF165
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