Interleukin-6 and soluble interleukin-6 receptor are elevated in large-vessel vasculitis: a cross-sectional and longitudinal study
To investigate serum levels of IL- 6 and soluble IL-6 receptor (sIL-6R) in patients with large-vessel vasculitis and their relationship with disease activity. Sera were obtained from 33 Takayasu's arteritis (TAK) patients and 14 giant cell arteritis (GCA) patients, and from 60 age-matched norma...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2017-03, Vol.35 Suppl 103 (1), p.102-110 |
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| container_title | Clinical and experimental rheumatology |
| container_volume | 35 Suppl 103 |
| creator | Pulsatelli, Lia Boiardi, Luigi Assirelli, Elisa Pazzola, Giulia Muratore, Francesco Addimanda, Olga Dolzani, Paolo Versari, Annibale Casali, Massimiliano Magnani, Luca Pignotti, Elettra Pipitone, Nicolò Croci, Stefania Meliconi, Riccardo Salvarani, Carlo |
| description | To investigate serum levels of IL- 6 and soluble IL-6 receptor (sIL-6R) in patients with large-vessel vasculitis and their relationship with disease activity.
Sera were obtained from 33 Takayasu's arteritis (TAK) patients and 14 giant cell arteritis (GCA) patients, and from 60 age-matched normal controls (NCs). Disease activity was assessed using 18F-FDG PET/CT and clinical indices including NIH/Kerr criteria and ITAS. Among TAK patients with active disease at baseline, clinical records and serum samples from 11 TAK patients were available for the longitudinal study. IL-6 and sIL-6R serum levels were evaluated using commercial ELISA kits.
IL-6 and sIL-6R serum levels were significantly higher in both GCA and TAK patients compared to NCs. IL-6 levels in TAK patients were significantly increased irrespective of disease phase, while a significant increase in sIL-6R concentrations was only found in TAK patients with active disease. Conversely, in GCA, IL-6 levels were significantly raised only in patients with active diseases, whereas sIL-6R levels appeared to be significantly higher irrespective of disease activity. Longitudinal analysis showed that levels of sIL-6R in TAK patients were significantly higher only at baseline, compared to NCs, whereas IL-6 levels were found to be significantly increased at each follow-up time point.
These overall results might suggest a role for sIL-6R as a potential biomarker for disease activity in TAK patients, whereas in GCA, modifications of IL-6 might better identify patients with active disease. |
| format | Article |
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Sera were obtained from 33 Takayasu's arteritis (TAK) patients and 14 giant cell arteritis (GCA) patients, and from 60 age-matched normal controls (NCs). Disease activity was assessed using 18F-FDG PET/CT and clinical indices including NIH/Kerr criteria and ITAS. Among TAK patients with active disease at baseline, clinical records and serum samples from 11 TAK patients were available for the longitudinal study. IL-6 and sIL-6R serum levels were evaluated using commercial ELISA kits.
IL-6 and sIL-6R serum levels were significantly higher in both GCA and TAK patients compared to NCs. IL-6 levels in TAK patients were significantly increased irrespective of disease phase, while a significant increase in sIL-6R concentrations was only found in TAK patients with active disease. Conversely, in GCA, IL-6 levels were significantly raised only in patients with active diseases, whereas sIL-6R levels appeared to be significantly higher irrespective of disease activity. Longitudinal analysis showed that levels of sIL-6R in TAK patients were significantly higher only at baseline, compared to NCs, whereas IL-6 levels were found to be significantly increased at each follow-up time point.
These overall results might suggest a role for sIL-6R as a potential biomarker for disease activity in TAK patients, whereas in GCA, modifications of IL-6 might better identify patients with active disease.</description><identifier>ISSN: 0392-856X</identifier><identifier>PMID: 28466804</identifier><language>eng</language><publisher>Italy</publisher><subject>Aged ; Biomarkers - blood ; Case-Control Studies ; Cluster Analysis ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Fluorodeoxyglucose F18 - administration & dosage ; Giant Cell Arteritis - blood ; Giant Cell Arteritis - diagnostic imaging ; Giant Cell Arteritis - immunology ; Humans ; Interleukin-6 - blood ; Longitudinal Studies ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Predictive Value of Tests ; Prognosis ; Radiopharmaceuticals - administration & dosage ; Receptors, Interleukin-6 - blood ; Severity of Illness Index ; Takayasu Arteritis - blood ; Takayasu Arteritis - diagnostic imaging ; Takayasu Arteritis - immunology ; Time Factors ; Up-Regulation</subject><ispartof>Clinical and experimental rheumatology, 2017-03, Vol.35 Suppl 103 (1), p.102-110</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28466804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pulsatelli, Lia</creatorcontrib><creatorcontrib>Boiardi, Luigi</creatorcontrib><creatorcontrib>Assirelli, Elisa</creatorcontrib><creatorcontrib>Pazzola, Giulia</creatorcontrib><creatorcontrib>Muratore, Francesco</creatorcontrib><creatorcontrib>Addimanda, Olga</creatorcontrib><creatorcontrib>Dolzani, Paolo</creatorcontrib><creatorcontrib>Versari, Annibale</creatorcontrib><creatorcontrib>Casali, Massimiliano</creatorcontrib><creatorcontrib>Magnani, Luca</creatorcontrib><creatorcontrib>Pignotti, Elettra</creatorcontrib><creatorcontrib>Pipitone, Nicolò</creatorcontrib><creatorcontrib>Croci, Stefania</creatorcontrib><creatorcontrib>Meliconi, Riccardo</creatorcontrib><creatorcontrib>Salvarani, Carlo</creatorcontrib><title>Interleukin-6 and soluble interleukin-6 receptor are elevated in large-vessel vasculitis: a cross-sectional and longitudinal study</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description>To investigate serum levels of IL- 6 and soluble IL-6 receptor (sIL-6R) in patients with large-vessel vasculitis and their relationship with disease activity.
Sera were obtained from 33 Takayasu's arteritis (TAK) patients and 14 giant cell arteritis (GCA) patients, and from 60 age-matched normal controls (NCs). Disease activity was assessed using 18F-FDG PET/CT and clinical indices including NIH/Kerr criteria and ITAS. Among TAK patients with active disease at baseline, clinical records and serum samples from 11 TAK patients were available for the longitudinal study. IL-6 and sIL-6R serum levels were evaluated using commercial ELISA kits.
IL-6 and sIL-6R serum levels were significantly higher in both GCA and TAK patients compared to NCs. IL-6 levels in TAK patients were significantly increased irrespective of disease phase, while a significant increase in sIL-6R concentrations was only found in TAK patients with active disease. Conversely, in GCA, IL-6 levels were significantly raised only in patients with active diseases, whereas sIL-6R levels appeared to be significantly higher irrespective of disease activity. Longitudinal analysis showed that levels of sIL-6R in TAK patients were significantly higher only at baseline, compared to NCs, whereas IL-6 levels were found to be significantly increased at each follow-up time point.
These overall results might suggest a role for sIL-6R as a potential biomarker for disease activity in TAK patients, whereas in GCA, modifications of IL-6 might better identify patients with active disease.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Cluster Analysis</subject><subject>Cross-Sectional Studies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - administration & dosage</subject><subject>Giant Cell Arteritis - blood</subject><subject>Giant Cell Arteritis - diagnostic imaging</subject><subject>Giant Cell Arteritis - immunology</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Radiopharmaceuticals - administration & dosage</subject><subject>Receptors, Interleukin-6 - blood</subject><subject>Severity of Illness Index</subject><subject>Takayasu Arteritis - blood</subject><subject>Takayasu Arteritis - diagnostic imaging</subject><subject>Takayasu Arteritis - immunology</subject><subject>Time Factors</subject><subject>Up-Regulation</subject><issn>0392-856X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkD1PwzAQhjOAaCn8BeSRJZLjrzpsqOKjUiUWkNgix75UBjcJPrtSV345AcrAdK_uffTodCfFnPKalVqq11lxjvhGKVNSLc-KGdNCKU3FvPhc9wligPzu-1IR0zuCQ8htAOL_NREsjGmIxEQgEGBvEriJIcHELZR7QIRA9gZtDj55vCGG2Dgglgg2-aE34ccehn7rU3b-e4FTOFwUp50JCJfHuShe7u-eV4_l5ulhvbrdlCOrqlQKyrkUmlXLWoCt-XQ_VdK2znadVmxJWdsK2jnV6U61vJZCVoxXRipnmeGWL4rrX-8Yh48MmJqdRwshmB6GjE2la1EzJiSb0KsjmtsduGaMfmfiofn7G_8C1zZqdA</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Pulsatelli, Lia</creator><creator>Boiardi, Luigi</creator><creator>Assirelli, Elisa</creator><creator>Pazzola, Giulia</creator><creator>Muratore, Francesco</creator><creator>Addimanda, Olga</creator><creator>Dolzani, Paolo</creator><creator>Versari, Annibale</creator><creator>Casali, Massimiliano</creator><creator>Magnani, Luca</creator><creator>Pignotti, Elettra</creator><creator>Pipitone, Nicolò</creator><creator>Croci, Stefania</creator><creator>Meliconi, Riccardo</creator><creator>Salvarani, Carlo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>Interleukin-6 and soluble interleukin-6 receptor are elevated in large-vessel vasculitis: a cross-sectional and longitudinal study</title><author>Pulsatelli, Lia ; Boiardi, Luigi ; Assirelli, Elisa ; Pazzola, Giulia ; Muratore, Francesco ; Addimanda, Olga ; Dolzani, Paolo ; Versari, Annibale ; Casali, Massimiliano ; Magnani, Luca ; Pignotti, Elettra ; Pipitone, Nicolò ; Croci, Stefania ; Meliconi, Riccardo ; Salvarani, Carlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-403354821794ec93680065cbdcff862702bb40fd6f8f6b395451231a56dc2a3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Cluster Analysis</topic><topic>Cross-Sectional Studies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - administration & dosage</topic><topic>Giant Cell Arteritis - blood</topic><topic>Giant Cell Arteritis - diagnostic imaging</topic><topic>Giant Cell Arteritis - immunology</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Radiopharmaceuticals - administration & dosage</topic><topic>Receptors, Interleukin-6 - blood</topic><topic>Severity of Illness Index</topic><topic>Takayasu Arteritis - blood</topic><topic>Takayasu Arteritis - diagnostic imaging</topic><topic>Takayasu Arteritis - immunology</topic><topic>Time Factors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pulsatelli, Lia</creatorcontrib><creatorcontrib>Boiardi, Luigi</creatorcontrib><creatorcontrib>Assirelli, Elisa</creatorcontrib><creatorcontrib>Pazzola, Giulia</creatorcontrib><creatorcontrib>Muratore, Francesco</creatorcontrib><creatorcontrib>Addimanda, Olga</creatorcontrib><creatorcontrib>Dolzani, Paolo</creatorcontrib><creatorcontrib>Versari, Annibale</creatorcontrib><creatorcontrib>Casali, Massimiliano</creatorcontrib><creatorcontrib>Magnani, Luca</creatorcontrib><creatorcontrib>Pignotti, Elettra</creatorcontrib><creatorcontrib>Pipitone, Nicolò</creatorcontrib><creatorcontrib>Croci, Stefania</creatorcontrib><creatorcontrib>Meliconi, Riccardo</creatorcontrib><creatorcontrib>Salvarani, Carlo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pulsatelli, Lia</au><au>Boiardi, Luigi</au><au>Assirelli, Elisa</au><au>Pazzola, Giulia</au><au>Muratore, Francesco</au><au>Addimanda, Olga</au><au>Dolzani, Paolo</au><au>Versari, Annibale</au><au>Casali, Massimiliano</au><au>Magnani, Luca</au><au>Pignotti, Elettra</au><au>Pipitone, Nicolò</au><au>Croci, Stefania</au><au>Meliconi, Riccardo</au><au>Salvarani, Carlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-6 and soluble interleukin-6 receptor are elevated in large-vessel vasculitis: a cross-sectional and longitudinal study</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>35 Suppl 103</volume><issue>1</issue><spage>102</spage><epage>110</epage><pages>102-110</pages><issn>0392-856X</issn><abstract>To investigate serum levels of IL- 6 and soluble IL-6 receptor (sIL-6R) in patients with large-vessel vasculitis and their relationship with disease activity.
Sera were obtained from 33 Takayasu's arteritis (TAK) patients and 14 giant cell arteritis (GCA) patients, and from 60 age-matched normal controls (NCs). Disease activity was assessed using 18F-FDG PET/CT and clinical indices including NIH/Kerr criteria and ITAS. Among TAK patients with active disease at baseline, clinical records and serum samples from 11 TAK patients were available for the longitudinal study. IL-6 and sIL-6R serum levels were evaluated using commercial ELISA kits.
IL-6 and sIL-6R serum levels were significantly higher in both GCA and TAK patients compared to NCs. IL-6 levels in TAK patients were significantly increased irrespective of disease phase, while a significant increase in sIL-6R concentrations was only found in TAK patients with active disease. Conversely, in GCA, IL-6 levels were significantly raised only in patients with active diseases, whereas sIL-6R levels appeared to be significantly higher irrespective of disease activity. Longitudinal analysis showed that levels of sIL-6R in TAK patients were significantly higher only at baseline, compared to NCs, whereas IL-6 levels were found to be significantly increased at each follow-up time point.
These overall results might suggest a role for sIL-6R as a potential biomarker for disease activity in TAK patients, whereas in GCA, modifications of IL-6 might better identify patients with active disease.</abstract><cop>Italy</cop><pmid>28466804</pmid><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0392-856X |
| ispartof | Clinical and experimental rheumatology, 2017-03, Vol.35 Suppl 103 (1), p.102-110 |
| issn | 0392-856X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Biomarkers - blood Case-Control Studies Cluster Analysis Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Female Fluorodeoxyglucose F18 - administration & dosage Giant Cell Arteritis - blood Giant Cell Arteritis - diagnostic imaging Giant Cell Arteritis - immunology Humans Interleukin-6 - blood Longitudinal Studies Male Middle Aged Positron Emission Tomography Computed Tomography Predictive Value of Tests Prognosis Radiopharmaceuticals - administration & dosage Receptors, Interleukin-6 - blood Severity of Illness Index Takayasu Arteritis - blood Takayasu Arteritis - diagnostic imaging Takayasu Arteritis - immunology Time Factors Up-Regulation |
| title | Interleukin-6 and soluble interleukin-6 receptor are elevated in large-vessel vasculitis: a cross-sectional and longitudinal study |
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