Activation of transforming growth factor‐β1 by thrombin via integrins αvβ1, αvβ3, and αvβ5 in buccal fibroblasts: Suppression by epigallocatechin‐3‐gallate

Background Transforming growth factor‐beta (TGF‐β) plays a central role in the pathogenesis of oral submucous fibrosis (OSF). Thrombin is a key player in tissue repair, inflammation, and fibrosis after injury. Methods Effects of thrombin on activated‐TGF‐β1 levels, Smad3 phosphorylation, and connect...

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Veröffentlicht in:	Head & neck 2017-07, Vol.39 (7), p.1436-1445
Hauptverfasser:	Chang, Jenny Zwei‐Chieng, Hsieh, Yu‐Ping, Lin, Wen‐Hsin, Chen, Hsin‐Ming, Kuo, Mark Yen‐Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western - methods Catechin - analogs & derivatives Catechin - metabolism Cells, Cultured Enzyme-Linked Immunosorbent Assay epigallocatechin‐3‐gallate (EGCG) fibroblast Fibroblasts - drug effects Fibroblasts - metabolism Humans Integrin alphaVbeta3 - drug effects Integrin alphaVbeta3 - metabolism Mouth Mucosa - metabolism Mouth Mucosa - pathology oral submucous fibrosis Oral Submucous Fibrosis - metabolism Oral Submucous Fibrosis - pathology Receptors, Vitronectin - metabolism Sensitivity and Specificity thrombin Thrombin - pharmacology Transforming Growth Factor beta1 - drug effects Transforming Growth Factor beta1 - metabolism transforming growth factor‐beta (TGF‐β)
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