Therapeutic glycoprotein production in mammalian cells

•The various mammalian and non-mammalian expression systems used for glycoprotein production are described.•We review recent cell engineering strategies developed to increase cell productivity.•The glycoengineering strategies used to reduce fucosylation and/or enhance sialylation of glycoproteins ar...

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Veröffentlicht in:	Journal of biotechnology 2017-06, Vol.251, p.128-140
Hauptverfasser:	Lalonde, Marie-Eve, Durocher, Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotherapeutics Cell Engineering Cell Line CHO cells Genomics Glycoengineering Glycoprotein Glycoproteins - biosynthesis Humans Recombinant Proteins - biosynthesis
Online-Zugang:	Volltext
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