Drug discovery targeted to the Alzheimer's APP mRNA 5'-untranslated region: the action of paroxetine and dimercaptopropanol

We screened for drugs that specifically interact with the 5'-untranslated region of the mRNA encoding the Alzheimer's amyloid precursor protein (APP). Our goal was to use newly discovered APP 5' UTR directed compounds to limit amyloid-beta (Abeta)-peptide output in cell culture system...

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Veröffentlicht in:	Journal of molecular neuroscience 2003, Vol.20 (3), p.267-276
Hauptverfasser:	Payton, Sandra, Cahill, Catherine M, Randall, Jeffrey D, Gullans, Steven R, Rogers, Jack T
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - antagonists & inhibitors 5' Untranslated Regions - metabolism Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - metabolism Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - biosynthesis Amyloid beta-Protein Precursor - genetics Anti-Bacterial Agents - pharmacology Azithromycin - pharmacology Cell Line, Tumor Chelating Agents - pharmacology Dimercaprol - pharmacology Drug Evaluation, Preclinical Genes, Reporter - drug effects Genes, Reporter - genetics Humans Luciferases - genetics Paroxetine - pharmacology Protein Synthesis Inhibitors - pharmacology RNA, Messenger - antagonists & inhibitors RNA, Messenger - metabolism Serotonin Uptake Inhibitors - pharmacology
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