Schwann cells synthesize alpha 7 beta 1 integrin which is dispensable for peripheral nerve development and myelination

Defects in laminins or laminin receptors are responsible for various neuromuscular disorders, including peripheral neuropathies. Interactions between Schwann cells and their basal lamina are fundamental to peripheral nerve development and successful myelination. Selected laminins are expressed in the endoneurium, and their receptors are developmentally regulated during peripheral nerve formation. Loss-of-function mutations have confirmed the importance and the role of some of these molecules. Here we show for the first time that another laminin receptor, alpha 7 beta 1 integrin, previously described only in neurons, is also expressed in Schwann cells. The expression of alpha 7 appears postnatally, such that alpha 7 beta 1 is the last laminin receptor expressed by differentiating Schwann cells. Genetic inactivation of the alpha 7 subunit in mice does not affect peripheral nerve formation or the expression of other laminin receptors. Of note, alpha 7 beta 1 is not necessary for basal lamina formation and myelination. Nonetheless, these data taken together with the previous demonstration of impaired axonal regrowth in alpha 7-null mice suggest a possible Schwann cell-autonomous role for alpha 7 in nerve regeneration.