Secretion of interleukin‐1β by astrocytes mediates endothelin‐1 and tumour necrosis factor‐α effects on human brain microvascular endothelial cell permeability

Evidence suggests that endothelin‐1 (ET‐1) plays an essential role in brain inflammation. However, whether ET‐1 contributes directly to blood–brain barrier (BBB) breakdown remains to be elucidated. Using an in vitro BBB model consisting of co‐cultures of human primary astrocytes and brain microvascu...

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Veröffentlicht in:	Journal of neurochemistry 2003-07, Vol.86 (1), p.246-254
Hauptverfasser:	Didier, Nathalie, Romero, Ignacio A., Créminon, Christophe, Wijkhuisen, Anne, Grassi, Jacques, Mabondzo, Aloïse
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences blood–brain barrier Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges endothelin‐1 Fundamental and applied biological sciences. Psychology interleukin 1^b interleukin‐1β neuropathogenesis tumour necrosis factor‐α Vertebrates: nervous system and sense organs
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