Minocycline enhances MPTP toxicity to dopaminergic neurons

Minocycline has been shown previously to have beneficial effects against ischemia in rats as well as neuroprotective properties against excitotoxic damage in vitro, nigral cell loss via 6‐hydroxydopamine, and to prolong the life‐span of transgenic mouse models of Huntington's disease (HD) and a...

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Veröffentlicht in:	Journal of neuroscience research 2003-10, Vol.74 (2), p.278-285
Hauptverfasser:	Yang, Lichuan, Sugama, Shuei, Chirichigno, Jason W., Gregorio, Jason, Lorenzl, Stefan, Shin, Dong H., Browne, Susan E., Shimizu, Yoshinori, Joh, Tong H., Beal, M. Flint, Albers, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenylpyridinium - pharmacology Animals Dopamine - metabolism Dose-Response Relationship, Drug doxycycline Doxycycline - pharmacology Drug Administration Schedule Drug Synergism Gliosis - drug therapy Gliosis - physiopathology Gliosis - prevention & control inflammation Male Mice Mice, Inbred C57BL Microglia - drug effects Microglia - physiology minocycline Minocycline - pharmacology Neostriatum - drug effects Neostriatum - metabolism Neostriatum - pathology Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - pharmacology Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - drug therapy Parkinsonian Disorders - physiopathology Substantia Nigra - drug effects Substantia Nigra - pathology Substantia Nigra - physiopathology Synaptic Vesicles - drug effects Synaptic Vesicles - metabolism tetracycline Tetracycline - pharmacology vesicles
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