Tacrolimus Dosing in Pediatric Heart Transplant Patients is Related to CYP3A5 and MDR1 Gene Polymorphisms

Tacrolimus is a substrate for P‐glycoprotein (P‐gp) and cytochrome (CYP) P4503A. P‐gp is encoded by the multiple drug resistance gene MDR1 and CYP3A is the major enzyme responsible for tacrolimus metabolism. Both MDR1 and CYP3A5 genes have multiple single nucleotide polymorphisms. The objective of t...

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Veröffentlicht in:	American journal of transplantation 2003-04, Vol.3 (4), p.477-483
Hauptverfasser:	Zheng, HongXia, Webber, Steven, Zeevi, Adriana, Schuetz, Erin, Zhang, Jiong, Bowman, Pamela, Boyle, Gerard, Law, Yuk, Miller, Susan, Lamba, Jatinder, Burckart, Gilbert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics Base Sequence Child CYP3A5 gene Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - genetics DNA Primers Dose-Response Relationship, Drug Heart Transplantation Humans Immunosuppressive Agents - administration & dosage MDR1 gene Multidrug resistance polymorphism Polymorphism, Genetic p‐glycoprotein tacrolimus Tacrolimus - administration & dosage tacrolimus dosing transplantation
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