Transformation of fatty acids catalyzed by cytochrome P450 monooxygenase enzymes of Candida tropicalis

Candida tropicalis ATCC 20336 can grow on fatty acids or alkanes as its sole source of carbon and energy, but strains blocked in beta-oxidation convert these substrates to long-chain alpha,omega-dicarboxylic acids (diacids), compounds of potential commercial value (Picataggio et al., Biotechnology 1...

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Veröffentlicht in:	Applied and Environmental Microbiology 2003-10, Vol.69 (10), p.5992-5999
Hauptverfasser:	Eschenfeldt, W.H, Zhang, Y, Samaha, H, Stols, L, Eirich, L.D, Wilson, C.R, Donnelly, M.I
Format:	Artikel
Sprache:	eng
Schlagworte:	a,^w-dicarboxylic acids alkanes Amino Acid Sequence Animals Baculoviridae - genetics BASIC BIOLOGICAL SCIENCES Biological and medical sciences CANDIDA Candida tropicalis Candida tropicalis - enzymology Candida tropicalis - genetics Carbon CARBOXYLIC ACIDS cell lines Cells, Cultured cytochrome P-450 Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism cytochrome P450 cytochrome P450 monooxygenase CYTOCHROMES enzyme activity ENZYMES Fatty acids Fatty Acids - metabolism Fundamental and applied biological sciences. Psychology Fungi gene expression GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE genes Genetic Vectors Microbiology microsomes Microsomes - enzymology molecular cloning myristic acid Myristic Acid - metabolism NADPH-Ferrihemoprotein Reductase - genetics NADPH-Ferrihemoprotein Reductase - metabolism oleic acid Oleic Acid - metabolism Oxidation Peptides - chemistry Physiology and Biotechnology recombinant proteins saturated fatty acids Spodoptera Spodoptera frugiperda Substrates TRANSFORMATIONS transgenic insects unsaturated fatty acids unspecific monooxygenase w-hydroxy acids
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