Novel flexible nerve conduits made of water‐based biodegradable polyurethane for peripheral nerve regeneration
Peripheral nerve conduits were fabricated from biodegradable polyurethane (PU) which was synthesized by a waterborne process. The biodegradable PU was based on poly(ε‐caprolactone) diol and polyethylene butylene adipate diol (2:3 molar ratio) as the soft segment. Conduits formed by the freeze‐drying...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2017-05, Vol.105 (5), p.1383-1392 |
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| container_title | Journal of biomedical materials research. Part A |
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| creator | Hsu, Shan‐hui Chang, Wen‐Chi Yen, Chen‐Tung |
| description | Peripheral nerve conduits were fabricated from biodegradable polyurethane (PU) which was synthesized by a waterborne process. The biodegradable PU was based on poly(ε‐caprolactone) diol and polyethylene butylene adipate diol (2:3 molar ratio) as the soft segment. Conduits formed by the freeze‐drying process had asymmetric microporous structure. The PU nerve conduits were used to bridge a 10‐mm gap in rat sciatic nerve. Nerve regeneration was evaluated by walking track analysis, magnetic resonance imaging (MRI), electrophysiological, and histological analyses. Results demonstrated that after 6 weeks, walking function was recovered by 40%. MR images showed that the transected nerve was reconnected after 3 weeks and the diameter of the regenerated nerve increased from 3 to 6 weeks. The nerve conduction velocity of the regenerated nerve reached 50% of the normal value after 6 weeks. Histological examination revealed that the cross‐sectional area of the regenerated nerve at the midconduit was 0.24 mm2 after 6 weeks. The efficacy of PU nerve conduits based on functional recovery and histology was superior to that of commercial conduits (Neurotube). The PU nerve conduit developed in this study may be a potential candidate for clinical peripheral nerve tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1383–1392, 2017. |
| doi_str_mv | 10.1002/jbm.a.36022 |
| format | Article |
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The biodegradable PU was based on poly(ε‐caprolactone) diol and polyethylene butylene adipate diol (2:3 molar ratio) as the soft segment. Conduits formed by the freeze‐drying process had asymmetric microporous structure. The PU nerve conduits were used to bridge a 10‐mm gap in rat sciatic nerve. Nerve regeneration was evaluated by walking track analysis, magnetic resonance imaging (MRI), electrophysiological, and histological analyses. Results demonstrated that after 6 weeks, walking function was recovered by 40%. MR images showed that the transected nerve was reconnected after 3 weeks and the diameter of the regenerated nerve increased from 3 to 6 weeks. The nerve conduction velocity of the regenerated nerve reached 50% of the normal value after 6 weeks. Histological examination revealed that the cross‐sectional area of the regenerated nerve at the midconduit was 0.24 mm2 after 6 weeks. The efficacy of PU nerve conduits based on functional recovery and histology was superior to that of commercial conduits (Neurotube). The PU nerve conduit developed in this study may be a potential candidate for clinical peripheral nerve tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1383–1392, 2017.</description><identifier>ISSN: 1549-3296</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.36022</identifier><identifier>PMID: 28152586</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Absorbable Implants ; Animals ; Biodegradability ; biodegradable polyurethane ; Biodegradation ; Conduits ; Diols ; Drying ; Histology ; Magnetic resonance imaging ; Nerve conduction ; nerve conduits ; Nerve Regeneration - drug effects ; Nerves ; NMR ; Nuclear magnetic resonance ; Peripheral Nerve Injuries - therapy ; peripheral nerve regeneration ; Peripheral nerves ; Polyesters - chemistry ; Polyesters - pharmacology ; Polyethylene ; Polyethylenes ; Polyurethane ; Polyurethane resins ; Polyurethanes - chemistry ; Polyurethanes - pharmacology ; Rats ; Recovery of function ; Regeneration ; Sciatic nerve ; Tissue engineering ; Walking</subject><ispartof>Journal of biomedical materials research. 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Part A</title><addtitle>J Biomed Mater Res A</addtitle><description>Peripheral nerve conduits were fabricated from biodegradable polyurethane (PU) which was synthesized by a waterborne process. The biodegradable PU was based on poly(ε‐caprolactone) diol and polyethylene butylene adipate diol (2:3 molar ratio) as the soft segment. Conduits formed by the freeze‐drying process had asymmetric microporous structure. The PU nerve conduits were used to bridge a 10‐mm gap in rat sciatic nerve. Nerve regeneration was evaluated by walking track analysis, magnetic resonance imaging (MRI), electrophysiological, and histological analyses. Results demonstrated that after 6 weeks, walking function was recovered by 40%. MR images showed that the transected nerve was reconnected after 3 weeks and the diameter of the regenerated nerve increased from 3 to 6 weeks. The nerve conduction velocity of the regenerated nerve reached 50% of the normal value after 6 weeks. Histological examination revealed that the cross‐sectional area of the regenerated nerve at the midconduit was 0.24 mm2 after 6 weeks. The efficacy of PU nerve conduits based on functional recovery and histology was superior to that of commercial conduits (Neurotube). The PU nerve conduit developed in this study may be a potential candidate for clinical peripheral nerve tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1383–1392, 2017.</description><subject>Absorbable Implants</subject><subject>Animals</subject><subject>Biodegradability</subject><subject>biodegradable polyurethane</subject><subject>Biodegradation</subject><subject>Conduits</subject><subject>Diols</subject><subject>Drying</subject><subject>Histology</subject><subject>Magnetic resonance imaging</subject><subject>Nerve conduction</subject><subject>nerve conduits</subject><subject>Nerve Regeneration - drug effects</subject><subject>Nerves</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Peripheral Nerve Injuries - therapy</subject><subject>peripheral nerve regeneration</subject><subject>Peripheral nerves</subject><subject>Polyesters - chemistry</subject><subject>Polyesters - pharmacology</subject><subject>Polyethylene</subject><subject>Polyethylenes</subject><subject>Polyurethane</subject><subject>Polyurethane resins</subject><subject>Polyurethanes - chemistry</subject><subject>Polyurethanes - pharmacology</subject><subject>Rats</subject><subject>Recovery of function</subject><subject>Regeneration</subject><subject>Sciatic nerve</subject><subject>Tissue engineering</subject><subject>Walking</subject><issn>1549-3296</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkr9u1TAUhy0EoqUwsSNLLEgoF_-PPZYKaFELC8yWkxy3uXLiYCctd-MReEaeBN_eSweGqot9hs-fz7F_CL2kZEUJYe_WzbByK64IY4_QIZWSVcIo-XhbC1NxZtQBepbzusCKSPYUHTBNJZNaHaLpS7yGgH2An30TAI-QrgG3ceyWfs54cB3g6PGNmyH9-fW7cRk63PSxg8vkOrc9MsWwWRLMV24E7GPCE6R-uoLkwl6X4BJK5eY-js_RE-9Chhf7_Qh9__jh28lpdf7109nJ8XnVCkNZVXsA1nInW0rrphZaGE81kXVZvRfCs1opCdB1jnpqqBOtaolugHBXK8n5EXqz804p_lggz3bocwshlC7jki3VhhuqODEPQLU2Uin1EFSV9yeK0YK-_g9dxyWNZWbLqBZccCn0fVS5lioj9O0wb3dUm2LOCbydUj-4tLGU2G0IbAmBdfY2BIV-tXcuzQDdHfvv1wvAdsBNH2Bzn8t-fn9xvLP-BWpVvQI</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Hsu, Shan‐hui</creator><creator>Chang, Wen‐Chi</creator><creator>Yen, Chen‐Tung</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201705</creationdate><title>Novel flexible nerve conduits made of water‐based biodegradable polyurethane for peripheral nerve regeneration</title><author>Hsu, Shan‐hui ; Chang, Wen‐Chi ; Yen, Chen‐Tung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4912-7fee2c3a5c117b74849f18057f18ff44f27665eedda1f191a4c6c08be03a76533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Absorbable Implants</topic><topic>Animals</topic><topic>Biodegradability</topic><topic>biodegradable polyurethane</topic><topic>Biodegradation</topic><topic>Conduits</topic><topic>Diols</topic><topic>Drying</topic><topic>Histology</topic><topic>Magnetic resonance imaging</topic><topic>Nerve conduction</topic><topic>nerve conduits</topic><topic>Nerve Regeneration - drug effects</topic><topic>Nerves</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Peripheral Nerve Injuries - therapy</topic><topic>peripheral nerve regeneration</topic><topic>Peripheral nerves</topic><topic>Polyesters - chemistry</topic><topic>Polyesters - pharmacology</topic><topic>Polyethylene</topic><topic>Polyethylenes</topic><topic>Polyurethane</topic><topic>Polyurethane resins</topic><topic>Polyurethanes - chemistry</topic><topic>Polyurethanes - pharmacology</topic><topic>Rats</topic><topic>Recovery of function</topic><topic>Regeneration</topic><topic>Sciatic nerve</topic><topic>Tissue engineering</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, Shan‐hui</creatorcontrib><creatorcontrib>Chang, Wen‐Chi</creatorcontrib><creatorcontrib>Yen, Chen‐Tung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, Shan‐hui</au><au>Chang, Wen‐Chi</au><au>Yen, Chen‐Tung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel flexible nerve conduits made of water‐based biodegradable polyurethane for peripheral nerve regeneration</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><addtitle>J Biomed Mater Res A</addtitle><date>2017-05</date><risdate>2017</risdate><volume>105</volume><issue>5</issue><spage>1383</spage><epage>1392</epage><pages>1383-1392</pages><issn>1549-3296</issn><eissn>1552-4965</eissn><abstract>Peripheral nerve conduits were fabricated from biodegradable polyurethane (PU) which was synthesized by a waterborne process. The biodegradable PU was based on poly(ε‐caprolactone) diol and polyethylene butylene adipate diol (2:3 molar ratio) as the soft segment. Conduits formed by the freeze‐drying process had asymmetric microporous structure. The PU nerve conduits were used to bridge a 10‐mm gap in rat sciatic nerve. Nerve regeneration was evaluated by walking track analysis, magnetic resonance imaging (MRI), electrophysiological, and histological analyses. Results demonstrated that after 6 weeks, walking function was recovered by 40%. MR images showed that the transected nerve was reconnected after 3 weeks and the diameter of the regenerated nerve increased from 3 to 6 weeks. The nerve conduction velocity of the regenerated nerve reached 50% of the normal value after 6 weeks. Histological examination revealed that the cross‐sectional area of the regenerated nerve at the midconduit was 0.24 mm2 after 6 weeks. The efficacy of PU nerve conduits based on functional recovery and histology was superior to that of commercial conduits (Neurotube). The PU nerve conduit developed in this study may be a potential candidate for clinical peripheral nerve tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1383–1392, 2017.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28152586</pmid><doi>10.1002/jbm.a.36022</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of biomedical materials research. Part A, 2017-05, Vol.105 (5), p.1383-1392 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Absorbable Implants Animals Biodegradability biodegradable polyurethane Biodegradation Conduits Diols Drying Histology Magnetic resonance imaging Nerve conduction nerve conduits Nerve Regeneration - drug effects Nerves NMR Nuclear magnetic resonance Peripheral Nerve Injuries - therapy peripheral nerve regeneration Peripheral nerves Polyesters - chemistry Polyesters - pharmacology Polyethylene Polyethylenes Polyurethane Polyurethane resins Polyurethanes - chemistry Polyurethanes - pharmacology Rats Recovery of function Regeneration Sciatic nerve Tissue engineering Walking |
| title | Novel flexible nerve conduits made of water‐based biodegradable polyurethane for peripheral nerve regeneration |
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