Inorganic nanoparticles as nucleic acid transporters into eukaryotic cells
The review is concerned with inorganic nanoparticles (gold, titanium dioxide, silica, iron oxides, calcium phosphate) used as nucleic acid transporters into mammalian cells. Methods for the synthesis of nanoparticles and approaches to surface modification through covalent or noncovalent attachment o...
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| Veröffentlicht in: | Russian chemical reviews 2017-01, Vol.86 (2), p.113-127 |
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| container_end_page | 127 |
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| container_issue | 2 |
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| container_title | Russian chemical reviews |
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| creator | Amirkhanov, Rinat N. Zarytova, Valentina F. Zenkova, Marina A. |
| description | The review is concerned with inorganic nanoparticles (gold, titanium dioxide, silica, iron oxides, calcium phosphate) used as nucleic acid transporters into mammalian cells. Methods for the synthesis of nanoparticles and approaches to surface modification through covalent or noncovalent attachment of low- or high-molecular-weight compounds are considered. The data available from the literature on biological action of nucleic acids delivered into the cells by nanoparticles and on the effect of nanoparticles and their conjugates and complexes on the cell survival are summarized. Pathways of cellular internalization of nanoparticles and the mechanism of their excretion, as well as the ways of release of nucleic acids from their complexes with nanoparticles after the cellular uptake are described. |
| doi_str_mv | 10.1070/RCR4604 |
| format | Article |
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Methods for the synthesis of nanoparticles and approaches to surface modification through covalent or noncovalent attachment of low- or high-molecular-weight compounds are considered. The data available from the literature on biological action of nucleic acids delivered into the cells by nanoparticles and on the effect of nanoparticles and their conjugates and complexes on the cell survival are summarized. Pathways of cellular internalization of nanoparticles and the mechanism of their excretion, as well as the ways of release of nucleic acids from their complexes with nanoparticles after the cellular uptake are described.</description><identifier>ISSN: 0036-021X</identifier><identifier>EISSN: 1468-4837</identifier><identifier>DOI: 10.1070/RCR4604</identifier><language>eng</language><publisher>London: Russian Academy of Sciences, Turpion Ltd and IOP Publishing</publisher><subject>Calcium phosphate ; Calcium phosphates ; Conjugates ; Covalence ; Iron oxides ; Lime ; Mammals ; Nanoparticles ; Nucleic acids ; Silicon dioxide ; Survival ; Titanium dioxide ; Uptakes</subject><ispartof>Russian chemical reviews, 2017-01, Vol.86 (2), p.113-127</ispartof><rights>2017 Russian Academy of Sciences, Turpion Ltd and IOP Publishing Ltd</rights><rights>Copyright IOP Publishing Mar 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-86671158d49258da4c6154e964acfb1e5fa71ac2f1ec6a42d667a59feace0a7d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1070/RCR4604/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>314,776,780,27903,27904,53824,53871</link.rule.ids></links><search><creatorcontrib>Amirkhanov, Rinat N.</creatorcontrib><creatorcontrib>Zarytova, Valentina F.</creatorcontrib><creatorcontrib>Zenkova, Marina A.</creatorcontrib><title>Inorganic nanoparticles as nucleic acid transporters into eukaryotic cells</title><title>Russian chemical reviews</title><addtitle>Russ. Chem. Rev</addtitle><description>The review is concerned with inorganic nanoparticles (gold, titanium dioxide, silica, iron oxides, calcium phosphate) used as nucleic acid transporters into mammalian cells. Methods for the synthesis of nanoparticles and approaches to surface modification through covalent or noncovalent attachment of low- or high-molecular-weight compounds are considered. The data available from the literature on biological action of nucleic acids delivered into the cells by nanoparticles and on the effect of nanoparticles and their conjugates and complexes on the cell survival are summarized. Pathways of cellular internalization of nanoparticles and the mechanism of their excretion, as well as the ways of release of nucleic acids from their complexes with nanoparticles after the cellular uptake are described.</description><subject>Calcium phosphate</subject><subject>Calcium phosphates</subject><subject>Conjugates</subject><subject>Covalence</subject><subject>Iron oxides</subject><subject>Lime</subject><subject>Mammals</subject><subject>Nanoparticles</subject><subject>Nucleic acids</subject><subject>Silicon dioxide</subject><subject>Survival</subject><subject>Titanium dioxide</subject><subject>Uptakes</subject><issn>0036-021X</issn><issn>1468-4837</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqN0F1LwzAUBuAgCs4p_oWCgt5Uc_LV9lKGH5OBMBS8C8c0lc4tqUl74b83Y4PhrrxJAnl4c_IScg70BmhBb-eTuVBUHJARCFXmouTFIRlRylVOGbwfk5MYF5RSqQo2Is9T58MnutZkDp3vMPStWdqYYczckE7pAk1bZ31AFzsfehti1rreZ3b4wvDjk8-MXS7jKTlqcBnt2XYfk7eH-9fJUz57eZxO7ma5EcD7vFSqAJBlLSqWVhRGgRS2UgJN8wFWNlgAGtaANQoFq5NHWTUWjaVY1HxMrje5XfDfg429XrVxPQE664eooax4laqQ8h-0hEKBqHiiF3t04Yfg0kc047JQnFG-DrzaKBN8jME2ugvtKtWggep1_Xpbf5KXG9n6bhcVTNCl0kwDcN3Vze7ZP2w_7BewF46m</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Amirkhanov, Rinat N.</creator><creator>Zarytova, Valentina F.</creator><creator>Zenkova, Marina A.</creator><general>Russian Academy of Sciences, Turpion Ltd and IOP Publishing</general><general>IOP Publishing</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7TM</scope></search><sort><creationdate>20170101</creationdate><title>Inorganic nanoparticles as nucleic acid transporters into eukaryotic cells</title><author>Amirkhanov, Rinat N. ; Zarytova, Valentina F. ; Zenkova, Marina A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-86671158d49258da4c6154e964acfb1e5fa71ac2f1ec6a42d667a59feace0a7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Calcium phosphate</topic><topic>Calcium phosphates</topic><topic>Conjugates</topic><topic>Covalence</topic><topic>Iron oxides</topic><topic>Lime</topic><topic>Mammals</topic><topic>Nanoparticles</topic><topic>Nucleic acids</topic><topic>Silicon dioxide</topic><topic>Survival</topic><topic>Titanium dioxide</topic><topic>Uptakes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amirkhanov, Rinat N.</creatorcontrib><creatorcontrib>Zarytova, Valentina F.</creatorcontrib><creatorcontrib>Zenkova, Marina A.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Russian chemical reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amirkhanov, Rinat N.</au><au>Zarytova, Valentina F.</au><au>Zenkova, Marina A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inorganic nanoparticles as nucleic acid transporters into eukaryotic cells</atitle><jtitle>Russian chemical reviews</jtitle><addtitle>Russ. Chem. Rev</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>86</volume><issue>2</issue><spage>113</spage><epage>127</epage><pages>113-127</pages><issn>0036-021X</issn><eissn>1468-4837</eissn><abstract>The review is concerned with inorganic nanoparticles (gold, titanium dioxide, silica, iron oxides, calcium phosphate) used as nucleic acid transporters into mammalian cells. Methods for the synthesis of nanoparticles and approaches to surface modification through covalent or noncovalent attachment of low- or high-molecular-weight compounds are considered. The data available from the literature on biological action of nucleic acids delivered into the cells by nanoparticles and on the effect of nanoparticles and their conjugates and complexes on the cell survival are summarized. 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| ispartof | Russian chemical reviews, 2017-01, Vol.86 (2), p.113-127 |
| issn | 0036-021X 1468-4837 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1893910755 |
| source | IOP Publishing Journals; Institute of Physics (IOP) Journals - HEAL-Link |
| subjects | Calcium phosphate Calcium phosphates Conjugates Covalence Iron oxides Lime Mammals Nanoparticles Nucleic acids Silicon dioxide Survival Titanium dioxide Uptakes |
| title | Inorganic nanoparticles as nucleic acid transporters into eukaryotic cells |
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