Application of Methyl Bisphosphine-Ligated Palladium Complexes for Low Pressure N- super(11)C-Acetylation of Peptides
A mild and effective method is described for super(11)C-labeling of peptides selectively at the N-terminal nitrogen or at internal lysine positions. The presented method relies on the use of specific biphosphine palladium-methyl complexes and their high reactivity towards amino-carbonylation of amin...
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| Veröffentlicht in: | Angewandte Chemie 2017-04, Vol.129 (16), p.4620-4624 |
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| container_issue | 16 |
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| container_title | Angewandte Chemie |
| container_volume | 129 |
| creator | Andersen, Thomas L Nordeman, Patrik Christoffersen, Heidi F Audrain, Helene Antoni, Gunnar Skrydstrup, Troels |
| description | A mild and effective method is described for super(11)C-labeling of peptides selectively at the N-terminal nitrogen or at internal lysine positions. The presented method relies on the use of specific biphosphine palladium-methyl complexes and their high reactivity towards amino-carbonylation of amine groups in the presence [ super(11)C]carbon monoxide. The protocol facilitates the production of native N- super(11)C-acetylated peptides, without any structural modifications and has been applied to a selection of bioactive peptides.Original Abstract: PET-Tracer aus super(11)CO: Die super(11)C-Markierung von Peptiden durch selektive N-Acetylierung am endstaendigen Stickstoff oder einer internen Lysinposition gelingt mit Methyl- und Biphosphan-ligierten Palladiumkomplexen in Gegenwart von [ super(11)C]Kohlenmonoxid. |
| doi_str_mv | 10.1002/ange.201700446 |
| format | Article |
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The protocol facilitates the production of native N- super(11)C-acetylated peptides, without any structural modifications and has been applied to a selection of bioactive peptides.Original Abstract: PET-Tracer aus super(11)CO: Die super(11)C-Markierung von Peptiden durch selektive N-Acetylierung am endstaendigen Stickstoff oder einer internen Lysinposition gelingt mit Methyl- und Biphosphan-ligierten Palladiumkomplexen in Gegenwart von [ super(11)C]Kohlenmonoxid.</description><identifier>ISSN: 0044-8249</identifier><identifier>EISSN: 1521-3757</identifier><identifier>DOI: 10.1002/ange.201700446</identifier><language>eng</language><subject>Amines ; Biocompatibility ; Low pressure ; Lysine ; Nitrogen ; Palladium ; Peptides</subject><ispartof>Angewandte Chemie, 2017-04, Vol.129 (16), p.4620-4624</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Andersen, Thomas L</creatorcontrib><creatorcontrib>Nordeman, Patrik</creatorcontrib><creatorcontrib>Christoffersen, Heidi F</creatorcontrib><creatorcontrib>Audrain, Helene</creatorcontrib><creatorcontrib>Antoni, Gunnar</creatorcontrib><creatorcontrib>Skrydstrup, Troels</creatorcontrib><title>Application of Methyl Bisphosphine-Ligated Palladium Complexes for Low Pressure N- super(11)C-Acetylation of Peptides</title><title>Angewandte Chemie</title><description>A mild and effective method is described for super(11)C-labeling of peptides selectively at the N-terminal nitrogen or at internal lysine positions. 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| issn | 0044-8249 1521-3757 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1893909220 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Amines Biocompatibility Low pressure Lysine Nitrogen Palladium Peptides |
| title | Application of Methyl Bisphosphine-Ligated Palladium Complexes for Low Pressure N- super(11)C-Acetylation of Peptides |
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