Accurate quantification of impurities in pure peptide material - angiotensin I: Comparison of calibration requirements and method performance characteristics of liquid chromatography coupled to hybrid tandem mass spectrometry and linear ion trap high-resolution mass spectrometry

Rationale The prohormone angiotensin I (ANG I) [amino acid sequence: DRVYIHPFHL] and other structurally related peptide hormones play an essential role in the regulation of the water and electrolyte balance in the human body as well as blood pressure. ANG I is a biomarker for hypertension and diabet...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2015-09, Vol.29 (18), p.1651-1660
Hauptverfasser:	Stoppacher, N., Josephs, R. D., Daireaux, A., Choteau, T., Westwood, S., Wielgosz, R. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin I - analysis Angiotensin I - chemistry Angiotensin I - standards Biomarkers - analysis Calibration Chromatography, Liquid - methods Chromatography, Liquid - standards High resolution Humans Impurities Linear Models Liquid chromatography Mass spectrometry Mathematical analysis Peptides Recombinant Proteins - analysis Recombinant Proteins - chemistry Recombinant Proteins - standards Reference Standards Reproducibility of Results Sensitivity and Specificity Systems analysis Tandem Mass Spectrometry - methods Tandem Mass Spectrometry - standards
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