Real time detection of live microbes using a highly sensitive bioluminescent nitroreductase probe

A highly sensitive and selective nitroreductase probe, showing a rapid and strong bioluminescence enhancement (>100-fold in 5 minutes), and its initial application in the real time detection of both Gram positive and Gram negative live bacteria and monitoring of their growth has been reported.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-03, Vol.51 (21), p.4440-4442
Hauptverfasser:	Wong, Roger H F, Kwong, Thomas, Yau, Kwok-Hei, Au-Yeung, Ho Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Benzothiazoles - chemistry Benzothiazoles - metabolism Bioluminescence Gram-Negative Bacteria - enzymology Gram-Negative Bacteria - growth & development Gram-Positive Bacteria - enzymology Gram-Positive Bacteria - growth & development Luciferases - metabolism Luminescent Measurements Microorganisms Molecular Probes - chemistry Molecular Probes - metabolism Monitoring Nitroreductases - chemistry Nitroreductases - metabolism Real time
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Beschreibung
Zusammenfassung:	A highly sensitive and selective nitroreductase probe, showing a rapid and strong bioluminescence enhancement (>100-fold in 5 minutes), and its initial application in the real time detection of both Gram positive and Gram negative live bacteria and monitoring of their growth has been reported.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c4cc10345a