Pluronic-PEI Micelles Reverse Multidrug Resistance by Depleting ATP and Inhibiting P-Glycoprotein for Colon Cancer Therapy
We have designed a polymer micelles based on Pluronic P123 and Polyethyleneimine 600 (termed as P123P600). Upon critical micelle concentration the P123P600 unimer formed micelles in water. These micelles not only could simultaneously delivery hydrophobic anticancer drug paclitaxel (PTX) to cancer ce...
Gespeichert in:
| Veröffentlicht in: | Materials Science Forum 2017-03, Vol.886, p.111-116 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 116 |
|---|---|
| container_issue | |
| container_start_page | 111 |
| container_title | Materials Science Forum |
| container_volume | 886 |
| creator | Wang, He Bin Liu, Kai Hang Li, Yang Zhou, Jun Tang, Gu Ping |
| description | We have designed a polymer micelles based on Pluronic P123 and Polyethyleneimine 600 (termed as P123P600). Upon critical micelle concentration the P123P600 unimer formed micelles in water. These micelles not only could simultaneously delivery hydrophobic anticancer drug paclitaxel (PTX) to cancer cells but also could deplete ATP and inhibit P-gp expression in MDR cells. In vitro researches demonstrated that these micelles showed the excellent biocompatibility, high drug loading efficiency, stably controlled releasing behavior, enhanced cellular up-take and improved serum stability. In vivo studies demonstrated that the PTX loaded micelles induced tumor cell apoptosis and inhibited the growth of tumor to overcome drug resistance through a synergistic effect. All these findings suggested that P123P600 for delivery of anticarcinogen provided a promising strategy for reversal of MDR in cancer treatment. |
| doi_str_mv | 10.4028/www.scientific.net/MSF.886.111 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1893889445</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1893889445</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3041-4b655e7f950ae496dbc3df8459e456a8071a477972fe6b274a396fa67170c27d3</originalsourceid><addsrcrecordid>eNqNkVtrGzEQRkUvUCftfxAUSl92I-3q-lIa3FwMMTGt-yy02tlYYaN1pd0a99dXjgMpfcrTwHDmmxkOQp8oKRmp1NlutyuT8xBG33lXBhjPlj8uS6VESSl9hWZUiKrQklev0UlNai4pJUy8QTNScV5wJsU7dJLSPSE1VVTM0J9VP8UheFesLhZ46R30PST8HX5DTICXUz_6Nk53uZN8Gm1wgJs9_gbbHkYf7vD5eoVtaPEibHzjH1ur4qrfu2EbhxF8wN0Q8Xzoh4Dnh_GI1xuIdrt_j952tk_w4ameop-XF-v5dXFze7WYn98UriaMFqwRnIPsNCcWmBZt4-q2U4xrYFxYRSS1TEotqw5EU0lmay06KySVxFWyrU_R52NuPujXBGk0Dz4d_rQBhikZqnStlGaMZ_Tjf-j9MMWQr8uUrJVUVOpMfTlSLg4pRejMNvoHG_eGEnPwZLIn8-zJZE8mezLZk8mecsDXY8AYbUgjuM0_e14W8Rf1g6I4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1873878179</pqid></control><display><type>article</type><title>Pluronic-PEI Micelles Reverse Multidrug Resistance by Depleting ATP and Inhibiting P-Glycoprotein for Colon Cancer Therapy</title><source>ProQuest Central Essentials</source><source>ProQuest Central (Alumni Edition)</source><source>ProQuest Central Student</source><source>Scientific.net Journals</source><creator>Wang, He Bin ; Liu, Kai Hang ; Li, Yang ; Zhou, Jun ; Tang, Gu Ping</creator><creatorcontrib>Wang, He Bin ; Liu, Kai Hang ; Li, Yang ; Zhou, Jun ; Tang, Gu Ping</creatorcontrib><description>We have designed a polymer micelles based on Pluronic P123 and Polyethyleneimine 600 (termed as P123P600). Upon critical micelle concentration the P123P600 unimer formed micelles in water. These micelles not only could simultaneously delivery hydrophobic anticancer drug paclitaxel (PTX) to cancer cells but also could deplete ATP and inhibit P-gp expression in MDR cells. In vitro researches demonstrated that these micelles showed the excellent biocompatibility, high drug loading efficiency, stably controlled releasing behavior, enhanced cellular up-take and improved serum stability. In vivo studies demonstrated that the PTX loaded micelles induced tumor cell apoptosis and inhibited the growth of tumor to overcome drug resistance through a synergistic effect. All these findings suggested that P123P600 for delivery of anticarcinogen provided a promising strategy for reversal of MDR in cancer treatment.</description><identifier>ISSN: 0255-5476</identifier><identifier>ISSN: 1662-9752</identifier><identifier>ISBN: 3035711046</identifier><identifier>ISBN: 9783035711042</identifier><identifier>EISSN: 1662-9752</identifier><identifier>DOI: 10.4028/www.scientific.net/MSF.886.111</identifier><language>eng</language><publisher>Pfaffikon: Trans Tech Publications Ltd</publisher><subject>Biocompatibility ; Cancer ; Cancer therapies ; Colon ; Colorectal cancer ; Depletion ; Drugs ; Efficiency ; Glycoproteins ; Inhibition ; Lymphocytes ; Materials science ; Micelles ; Tumors</subject><ispartof>Materials Science Forum, 2017-03, Vol.886, p.111-116</ispartof><rights>2017 Trans Tech Publications Ltd</rights><rights>Copyright Trans Tech Publications Ltd. Mar 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3041-4b655e7f950ae496dbc3df8459e456a8071a477972fe6b274a396fa67170c27d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://www.scientific.net/Image/TitleCover/4454?width=600</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1873878179?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21389,21390,23256,27924,27925,33530,33531,33703,33704,34314,34315,43659,43787,44067</link.rule.ids></links><search><creatorcontrib>Wang, He Bin</creatorcontrib><creatorcontrib>Liu, Kai Hang</creatorcontrib><creatorcontrib>Li, Yang</creatorcontrib><creatorcontrib>Zhou, Jun</creatorcontrib><creatorcontrib>Tang, Gu Ping</creatorcontrib><title>Pluronic-PEI Micelles Reverse Multidrug Resistance by Depleting ATP and Inhibiting P-Glycoprotein for Colon Cancer Therapy</title><title>Materials Science Forum</title><description>We have designed a polymer micelles based on Pluronic P123 and Polyethyleneimine 600 (termed as P123P600). Upon critical micelle concentration the P123P600 unimer formed micelles in water. These micelles not only could simultaneously delivery hydrophobic anticancer drug paclitaxel (PTX) to cancer cells but also could deplete ATP and inhibit P-gp expression in MDR cells. In vitro researches demonstrated that these micelles showed the excellent biocompatibility, high drug loading efficiency, stably controlled releasing behavior, enhanced cellular up-take and improved serum stability. In vivo studies demonstrated that the PTX loaded micelles induced tumor cell apoptosis and inhibited the growth of tumor to overcome drug resistance through a synergistic effect. All these findings suggested that P123P600 for delivery of anticarcinogen provided a promising strategy for reversal of MDR in cancer treatment.</description><subject>Biocompatibility</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Colon</subject><subject>Colorectal cancer</subject><subject>Depletion</subject><subject>Drugs</subject><subject>Efficiency</subject><subject>Glycoproteins</subject><subject>Inhibition</subject><subject>Lymphocytes</subject><subject>Materials science</subject><subject>Micelles</subject><subject>Tumors</subject><issn>0255-5476</issn><issn>1662-9752</issn><issn>1662-9752</issn><isbn>3035711046</isbn><isbn>9783035711042</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkVtrGzEQRkUvUCftfxAUSl92I-3q-lIa3FwMMTGt-yy02tlYYaN1pd0a99dXjgMpfcrTwHDmmxkOQp8oKRmp1NlutyuT8xBG33lXBhjPlj8uS6VESSl9hWZUiKrQklev0UlNai4pJUy8QTNScV5wJsU7dJLSPSE1VVTM0J9VP8UheFesLhZ46R30PST8HX5DTICXUz_6Nk53uZN8Gm1wgJs9_gbbHkYf7vD5eoVtaPEibHzjH1ur4qrfu2EbhxF8wN0Q8Xzoh4Dnh_GI1xuIdrt_j952tk_w4ameop-XF-v5dXFze7WYn98UriaMFqwRnIPsNCcWmBZt4-q2U4xrYFxYRSS1TEotqw5EU0lmay06KySVxFWyrU_R52NuPujXBGk0Dz4d_rQBhikZqnStlGaMZ_Tjf-j9MMWQr8uUrJVUVOpMfTlSLg4pRejMNvoHG_eGEnPwZLIn8-zJZE8mezLZk8mecsDXY8AYbUgjuM0_e14W8Rf1g6I4</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Wang, He Bin</creator><creator>Liu, Kai Hang</creator><creator>Li, Yang</creator><creator>Zhou, Jun</creator><creator>Tang, Gu Ping</creator><general>Trans Tech Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SR</scope><scope>7XB</scope><scope>88I</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>M2P</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20170301</creationdate><title>Pluronic-PEI Micelles Reverse Multidrug Resistance by Depleting ATP and Inhibiting P-Glycoprotein for Colon Cancer Therapy</title><author>Wang, He Bin ; Liu, Kai Hang ; Li, Yang ; Zhou, Jun ; Tang, Gu Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3041-4b655e7f950ae496dbc3df8459e456a8071a477972fe6b274a396fa67170c27d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biocompatibility</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Colon</topic><topic>Colorectal cancer</topic><topic>Depletion</topic><topic>Drugs</topic><topic>Efficiency</topic><topic>Glycoproteins</topic><topic>Inhibition</topic><topic>Lymphocytes</topic><topic>Materials science</topic><topic>Micelles</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, He Bin</creatorcontrib><creatorcontrib>Liu, Kai Hang</creatorcontrib><creatorcontrib>Li, Yang</creatorcontrib><creatorcontrib>Zhou, Jun</creatorcontrib><creatorcontrib>Tang, Gu Ping</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Engineered Materials Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Materials Science Forum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, He Bin</au><au>Liu, Kai Hang</au><au>Li, Yang</au><au>Zhou, Jun</au><au>Tang, Gu Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pluronic-PEI Micelles Reverse Multidrug Resistance by Depleting ATP and Inhibiting P-Glycoprotein for Colon Cancer Therapy</atitle><jtitle>Materials Science Forum</jtitle><date>2017-03-01</date><risdate>2017</risdate><volume>886</volume><spage>111</spage><epage>116</epage><pages>111-116</pages><issn>0255-5476</issn><issn>1662-9752</issn><eissn>1662-9752</eissn><isbn>3035711046</isbn><isbn>9783035711042</isbn><abstract>We have designed a polymer micelles based on Pluronic P123 and Polyethyleneimine 600 (termed as P123P600). Upon critical micelle concentration the P123P600 unimer formed micelles in water. These micelles not only could simultaneously delivery hydrophobic anticancer drug paclitaxel (PTX) to cancer cells but also could deplete ATP and inhibit P-gp expression in MDR cells. In vitro researches demonstrated that these micelles showed the excellent biocompatibility, high drug loading efficiency, stably controlled releasing behavior, enhanced cellular up-take and improved serum stability. In vivo studies demonstrated that the PTX loaded micelles induced tumor cell apoptosis and inhibited the growth of tumor to overcome drug resistance through a synergistic effect. All these findings suggested that P123P600 for delivery of anticarcinogen provided a promising strategy for reversal of MDR in cancer treatment.</abstract><cop>Pfaffikon</cop><pub>Trans Tech Publications Ltd</pub><doi>10.4028/www.scientific.net/MSF.886.111</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0255-5476 |
| ispartof | Materials Science Forum, 2017-03, Vol.886, p.111-116 |
| issn | 0255-5476 1662-9752 1662-9752 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1893889445 |
| source | ProQuest Central Essentials; ProQuest Central (Alumni Edition); ProQuest Central Student; Scientific.net Journals |
| subjects | Biocompatibility Cancer Cancer therapies Colon Colorectal cancer Depletion Drugs Efficiency Glycoproteins Inhibition Lymphocytes Materials science Micelles Tumors |
| title | Pluronic-PEI Micelles Reverse Multidrug Resistance by Depleting ATP and Inhibiting P-Glycoprotein for Colon Cancer Therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T00%3A50%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pluronic-PEI%20Micelles%20Reverse%20Multidrug%20Resistance%20by%20Depleting%20ATP%20and%20Inhibiting%20P-Glycoprotein%20for%20Colon%20Cancer%20Therapy&rft.jtitle=Materials%20Science%20Forum&rft.au=Wang,%20He%20Bin&rft.date=2017-03-01&rft.volume=886&rft.spage=111&rft.epage=116&rft.pages=111-116&rft.issn=0255-5476&rft.eissn=1662-9752&rft.isbn=3035711046&rft.isbn_list=9783035711042&rft_id=info:doi/10.4028/www.scientific.net/MSF.886.111&rft_dat=%3Cproquest_cross%3E1893889445%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1873878179&rft_id=info:pmid/&rfr_iscdi=true |