Advances in the molecular understanding of biological zinc transport
Between 5 and 10% of all proteins of a given organism are estimated to require zinc for function, and hence zinc is essential for almost any given metabolic process. It is therefore of great interest to understand major players and mechanisms that ensure the tight and correct control of zinc distrib...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2015-03, Vol.51 (22), p.4544-4563 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Blindauer, Claudia A |
| description | Between 5 and 10% of all proteins of a given organism are estimated to require zinc for function, and hence zinc is essential for almost any given metabolic process. It is therefore of great interest to understand major players and mechanisms that ensure the tight and correct control of zinc distribution and speciation in organisms and their individual cells. Significant progress has been made in recent years regarding 3-dimensional structures and modes of action of zinc sensor proteins, membrane-bound zinc transporters for cellular and sub-cellular uptake and efflux, as well as intracellular binding proteins. This feature article highlights advances in structures, zinc-binding sites and thermodynamics of proteins that are involved in zinc homeostasis and trafficking, including developments in understanding the metal selectivity of proteins. |
| doi_str_mv | 10.1039/c4cc10174j |
| format | Article |
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| ispartof | Chemical communications (Cambridge, England), 2015-03, Vol.51 (22), p.4544-4563 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; Royal Society of Chemistry E-Journals |
| subjects | Binding Biological Transport Efflux Homeostasis Models, Molecular Organisms Organometallic Compounds - chemistry Organometallic Compounds - metabolism Proteins Proteins - chemistry Proteins - metabolism Speciation Thermodynamics Uptakes Zinc Zinc - chemistry Zinc - metabolism |
| title | Advances in the molecular understanding of biological zinc transport |
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