The importance of loop length on the stability of i-motif structures

The importance of loop length on the stability of i-motif structures

Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to previous statements, it is the shorter loops that exhibit the highest stability.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-04, Vol.51 (26), p.5630-5632
Hauptverfasser: Gurung, Sarah P, Schwarz, Christine, Hall, James P, Cardin, Christine J, Brazier, John A
Format: Artikel
Sprache:eng
Schlagworte:
Circular Dichroism
DNA - chemistry
Hydrogen-Ion Concentration
Nucleotide Motifs
Spectrophotometry, Ultraviolet
Spectroscopy
Structural stability
Temperature
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Beschreibung
Zusammenfassung:Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to previous statements, it is the shorter loops that exhibit the highest stability.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc07279k